Nov
21
Mon
Advancing Biological Imaging and Sensing Using Quantum Technologies @ Maryland Hall 103
Nov 21 @ 2:00 pm – 3:00 pm

Advancing Biological Imaging and Sensing Using Quantum Technologies with Warwick Bowen.

Quantum technologies can exponentially accelerate computer simulations and detect signals that would be invisible to other technologies. This provides the potential for wide impact across the biosciences: better modelling of biochemical processes, and better imaging of biological systems. In this talk I will provide an overview of this potential, and how it could create a new field of quantum biotechnology. As an illustrative example, I will then introduce work in my laboratory that uses quantum correlated light to enhance bioimaging. In that work, we demonstrate for the first time that quantum correlations can be used to evade photochemical intrusion on the biological specimen, and therefore to observe biological structures that would be otherwise inaccessible. We achieve this in a coherent Raman microscope, providing chemically-specific information about the cell. Our results represents the first demonstration of absolute quantum advantage in biological microscopy, and we hope will open the door to a bright future for quantum bioimaging.

Professor Bowen’s research focuses on the implications of quantum science on precision measurement, and applications of quantum measurement in areas ranging from quantum condensed matter physics to the biosciences. He is the Director of the just announced Australian Research Council Centre of Excellence in Quantum Biotechnology. He is also a Fellow of the Australian Institute of Physics, Director of the University of Queensland Precision Technologies Translation Hub, and a Theme Leader of the Australian Centre for Engineered Quantum Systems. Prof Bowen’s research is supported by the Australian Research Council, the US Air Force Office of Scientific Research, Lockheed Martin, the US Army Research Office and the Australian Defence Science and Technology Group.

 

Dec
1
Thu
Probing and Attacking the Cancer Surfacome @ Virtual
Dec 1 @ 12:00 pm – 1:00 pm

Probing and Attacking the Cancer Surfacome with Jim Wells, PhD

The cell surface proteome(surfaceome)is a major hub for cellular communication and a primary source of drug targets, especially for biologics. My lab is interested in developing proteomic means to probe how the surfaceome changes in health and disease, especially cancer. Such changes involve alteration in protein expression and post-translational modifications such as proteolysis. I’ll describe new engineered tools we have built to probe the surfaceome changes that occur when oncogenes are expressed in isogenic cell lines to identify targets of interest. We then target proteins either upregulated, proteolyzed or both with recombinant antibodies derived by phage display to be used as validation tools and potential therapeutic leads

Jim received his BA from University of California at Berkeley, PhD from Washington State University (with Ralph Yount), and post-doc at Stanford (with George Stark), prior to joining Genentech, then Sunesis Pharmaceuticals, and finally UCSF. Wells’ group pioneered the engineering of proteins, antibodies, and small molecules that target catalytic, allosteric, and protein-protein interaction sites; and technologies including protein phage display, alanine-scanning, engineered proteases, bioconjugations, N-terminomics, disulfide “tethering”, and more recently an industrialized recombinant antibody production pipeline for the proteome. His team was integral to several protein products including Somavert for acromegaly, Avastin for cancer, Lifitegrast for dry eye disease, and engineered proteases sold by Pfizer, Genentech, Shire and Genencor, respectively. He is an elected member of the US National Academy of Science, American Association of Arts and Science, and the National Academy of Inventors.

This is a virtual event on Zoom. Click here to get the link.

Jan
3
Tue
Advances in Immunoengineering: Fundamentals and Cutting Edge Advances (2023) @ Virtual
Jan 3 @ 4:00 pm – Jan 19 @ 5:30 pm
Advances in Immunoengineering: Fundamentals and Cutting Edge Advances (2023) @ Virtual

The Advances in Immunoengineering: Fundamentals and Cutting Edge Advances workshop is hosted by Johns Hopkins Translational Immunoengineering. The workshop meets twice a week for three weeks and participants are eligible for CME credit. The workshop is also offered as a two-credit course to Johns Hopkins students

The immunoengineering field is transforming cancer, autoimmunity, regeneration, and transplantation treatments by combining the diverse and complex fields of engineering and immunology. There is a significant need to train engineers in immunology and immunologists in quantitative engineering techniques. Moreover, there is a need to bridge basic immunological discoveries with advances in clinical application. This workshop will review immune system fundamentals and components, engineering strategies to modulate the immune system, and clinical applications.

After attending this workshop, the learner will demonstrate the ability to:
– Review the fundamentals and recent discoveries in the function of the immune system.
– Identify engineering strategies to manipulate the immune system.
– Describe the clinical applications of immunoengineering.

The full schedule, speakers, topics, and registration information are available on JH-TIE’s website.