ACS Nano editor leads June 30 INBT seminar

Penelope Lewis, acquisitions editor for the journal ACS Nano will lead the next professional development seminar for Johns Hopkins Institute for NanoBioTechnology (INBT) on June 30 at 11 a.m. in Maryland 110. These seminars aim to expand students’ knowledge of issues and ideas relevant to but outside of the laboratory and classroom experience.

Penelope Lewis

Lewis, acquisitions editor of the American Chemical Society’s journal, ACS Nano. Lewis, earned a Ph.D. in chemistry from Penn State University. She will talk about her experience as a scientist moving into the world of academic publishing.

“A career in scholarly publishing can be an interesting and rewarding path for graduate students or post-docs who are looking to move away from the lab bench but still be surrounded by scientific research. In scientific publishing, a doctoral degree or a postdoc is always a great strength and for many positions a requirement. In this talk, I will describe the daily activities involved in working at a non-profit publisher, including the skills and interests that are helpful to succeed in this position,” Lewis said.

All JHU/JHMI and APL faculty, staff and students are invited to attend these free seminars, designed to promote discussion and interaction with scientific and engineering professionals. To find out the location and to RSVP for each seminar, please contact Ashanti Edwards at ashanti@jhu.edu.

Melissaratos opens INBT summer seminar series, June 16

Aris Melissaratos, senior advisor to the president for enterprise development at Johns Hopkins Technology Transfer, will speak at the summer’s first Professional Development Seminar hosted by the Johns Hopkins Institute for NanoBioTechnology (INBT) on June 16 at 11 a.m. in Maryland Hall 110.

A Hopkins’ electrical engineering graduate (‘66), Melissaratos will discuss the importance of technology on academic development and how it affects the standard of living, opportunities of the future, and solves global discrepancies. Melissaratos claims that he has “lots of warnings and advice” to offer, in addition to the benefit of “50 years of industry” experience.

Wednesday’s talk will include excerpts and topics from his new book, Innovation: The Key to Prosperity—Technology and America’s Role in the 21st Century Global Economy, cowritten with N.J Slabbert, which focuses on the translation side of the industry and how to transfer technology. The book “reveals America’s greatest wealth: its scientific and inventive ingenuity” and discusses how to harness and utilize that wealth for its full potential.

Melissaratos is a whiz at developing and financing a product and creating a business around a product. A true product of a research institute, Melissaratos” book “reminds us of the power and adventure of human intelligence,” wrote Gilbert F. Decker, former Science Advisor to the US Secretary of Defense in a review of the book. Topics to look forward to include: redeveloping the American economy to regain supremacy, upping our competitive edge in the global economy, and making up for our country’s lost manufacturing base with research.

Melissaratos has previously served as the vice president of science and technology and chief technology officer at Westinghouse Electronics corporate headquarters in Pittsburgh. He left to join state government in 2003 as Secretary of the Maryland Department of Business and Economic Development. His list of impressive credentials include holding the vice presidency title at Thermo Electron Corp., founding Armel Private Equity Investments, founding the Greater Baltimore Technology Council (co-chair), and serving as vice president of the Maryland Chamber of Commerce.

Four seminars will be held this summer. To attend any of INBT’s Professional Development Seminars, RSVP to Ashanti Edwards at Ashanti@jhu.edu.

For more information: INBT Professional Development Seminar Series, The Aris Institute

Story by Sarah Gubara, Senior, Psychology, Krieger School of Arts and Sciences

Lights! Camera! Science!

 

INBT Web Director Martin Rietveld works on protocol video with PhD student Yu-Ja Huang. (Photo:MSpiro)

Everything about movie making seems so glamorous. From beautiful stars to special effects, making films might appear magical. But actually, when you break it down, shooting a film is not unlike performing experiments in a lab. And, just as reading the script would be far less entertaining as seeing a film, reading a protocol might be confusing until the steps were performed in real life.

That’s the philosophy behind a new effort at Johns Hopkins Institute for NanoBioTechnology: produce short films describing recently published research and the protocols that go with them. The movies are produced collaboratively with INBT’s science writer Mary Spiro, INBT’s Animation Studio director Martin Rietveld, and the scientists and engineers involved.

The INBT Animation Studio already has several research-oriented films to its credit. The animation skills of Rietveld and his student crew have taken us inside a lipid bilayer and carried us along a fiber of collagen. INBT also has produced several video news releases using the talent of students in the annual science communication course.

Recently, however, INBT produced its first film describing a protocol from Nature Methods. Investigators Bridget Wildt, a PhD in materials science and engineering, Peter Searson, Reynolds Professor of Materials Science and Engineering, and Denis Wirtz, Smoot Professor of Chemical and Biomolecular Engineering, served as technical consultants for the production. The research was part of Johns Hopkins Engineering in Oncology Center, of which Wirtz is the director.

Materials science and engineering PhD candidate Yu-Ja Huang performs each step in assembling the Hopkins team’s device and demonstrates how to conduct programmed cell detachment experiments. “Studying cell detachment at the subcellular level is critical to understanding the way cancer cells metastasize,” Searson said. “Development of scientific methods to study cell detachment may guide us to prevent, limit or slow down the deadly spreading of cancer cells.”

Using a draft script developed by Wildt and Searson, Spiro simplified the text further for narrator, materials science and engineering PhD candidate Andrew Wong. Rietveld recorded Huang as he performed the protocol and refined the script further during filming. Viewing the final cut, Wong was able to read the script in a conversational and friendly tone.

You can watch the version of this new protocol video on INBT’s YouTube channel. The film may never earn an Academy Award, but we hope it will help specialists, and even the general public, to understand this unusual and complex procedure.

Related Links:

Check our INBT’s channel on YouTube.

Engineering in Oncology Center

Story by Mary Spiro

INBT welcomes 16 summer nanobio research interns

For 10 weeks this summer, 16 students from universities across the country will join the highly competitive Johns Hopkins Institute for Nanobiotechnology (INBT) Research Experience for Undergraduates (REU). The internship is funded by the National Science Foundation (NSF) and is supported and administered by INBT.

This is the third year of INBT’s REU program, and this group represents the institute’s largest group. Students are being mentored by faculty, graduate students and postdoctoral fellows in INBT affiliated laboratories across Hopkins. At the end of the 10-week research program, they will present their findings at a university-wide collaborative research poster session held with other summer interns from across several divisions.

In November 2009, NSF reported that over the last decade 10 times more white students will have earned doctoral degrees in science and engineering disciplines than minority students. Acknowledging this fact yet resolving not to accept it as status quo, INBT has employed aggressive measures to increase the number of individuals from underrepresented groups who apply to its educational programs.

“The nanobiotechnology REU has been one of the most successful and popular programs for INBT,” says Ashanti Edwards, senior education program coordinator for the institute. “The program has consistently attracted the best and the brightest students interested in research from top universities across the nation. The REU program was launched as a conduit to attract highly talented and motivated research students to pursue academic careers in research, particularly women and minority scholars. The program is highly competitive. For summer 2010, the number of applicants for the 10 slots in the program rose to nearly 500, twice what it had been the year before.”

Johns Hopkins Institute for NanoBioTechnology Summer REU Students. (Photos by Mary Spiro)

INBT’s summer 2010 REU students include pictured from top to bottom, from left to right:

Top row

Joshua Austin, computer science and math major from UMBC, is working with Jeff Gray, associate professor of chemical and biomolecular engineering, Whiting School of Engineering.

Mary Bedard, biochemistry and Spanish major from Elon University, is working with J.D. Tovar, assistant professor of chemistry, Krieger School of Arts and Sciences.

Kameron Black, neuroscience major from the University of California, Riverside, is working in the lab of Ted Dawson, professor of neuroscience, School of Medicine

Obafemi Ifelowo, who majors in molecular biology, biochemistry and bioinformatics at Towson University, is working with Jordan Green, assistant professor of biomedical engineering, School of Medicine.

Second row

Alfred Irungu, mechanical engineering major at UMBC, is working with German Drazer, assistant professor of chemical and biomolecular engineering, Whiting School of Engineering.

Ceslee Montgomery, human biology major from Stanford University, is working in the lab of Doug Robinson, associate professor of cell biology, School of Medicine.

Makeda Moore, biology major from Alabama A & M University, is working with Sharon Gerecht, assistant professor of chemical and biomolecular Engineering, Whiting School of Engineering.

Christopher Ojeda, biomedical engineering major from New Jersey Institute of Technology, is working in the lab of Michael Yu, assistant professor of Materials Science and Engineering, Whiting School of Engineering.

Third row

Katrin Passlack, mechanical engineering and kinesiology major at the University of Oklahoma, is working with Jeff Wang, associate professor of mechanical engineering, Whiting School of Engineering.

Roberto Rivera, chemical engineering major from the University of Puerto Rico, Mayaguez, is working in the lab of Nina Markovic, associate professor of physics, Krieger School of Arts and Sciences.

D. Kyle Robinson, bioengineering major from Oregon State University, is working in the lab of Denis Wirtz, professor of chemical and biomolecular engineering, Whiting School of Engineering. In addition, Kyle is the first REU intern for Johns Hopkins new Engineering in Oncology Center, of which Wirtz is director.

Russell Salamo, biology major from the University of Arkansas, is working with Kalina Hristova, associate professor of materials science and engineering, Whiting School of Engineering.

Bottom row

Quinton Smith, major in chemical engineering with a bioengineering concentration from the University of New Mexico, is working with Sharon Gerecht, assistant professor of chemical and biomolecular engineering, Whiting School of Engineering.

David To, chemistry major from Wittenberg University, is working with assistant professor Hai-Quan Mao in the department of materials science and engineering, Whiting School of Engineering.

Alan Winter, biology systems engineering major from Kansas State University, is working with Professor Peter Searson in the department of materials science and engineering, Whiting School of Engineering. Searson is the director of INBT.

Mary Zuniga, biology major a Northern Arizona University, is working in the lab of David Gracias, associate professor of chemical and biomolecular engineering, Whiting School of Engineering.

Related Links:

Johns Hopkins NanoBio Research Experience for Undergraduates

Professional development seminars kick off with talks on tech transfer, publishing

Aris Melissaratos

UPDATED TIMES AND LOCATIONS

Johns Hopkins Institute for NanoBioTechnology (INBT) will host four free professional development seminars for scientists and engineers this summer. These seminars aim to expand students’ knowledge of issues and ideas relevant to but outside of the laboratory and classroom experience.

Topics include intellectual property, commercialization and entrepreneurship, science journalism and publishing, ‘life after college” and much more. This summer, talks will be held Wednesdays at 11 a.m. on June 16, June 30, July 14 and July 28. Talks on June 16 and June 30 will be held in Maryland 110; talks on July 14 and July 28 will move to Ames 234.

Talks scheduled so far include:

June 16: Aris Melissaratos, senior advisor to the president from Johns Hopkins University Technology Transfer, will discuss what it takes for an research idea to move from bench to the commercial market. Johns Hopkins Technology Transfer is the office that links university researchers and businesses interested in commercializing their inventions.

June 30:  Penelope Lewis, acquisitions editor of the American Chemical Society’s journal, ACS Nano. Lewis, who earned a PhD in Chemistry from Penn State University, will talk about her experience as a scientist moving into the world of academic publishing.

Penelope Lewis

“A career in scholarly publishing can be an interesting and rewarding path for graduate students or postdocs who are looking to move away from the lab bench but still be surrounded by scientific research. In scientific publishing, a doctoral degree or a postdoc is always a great strength and for many positions a requirement. In this talk, I will describe the daily activities involved in working at a non-profit publisher, including the skills and interests that are helpful to succeed in this position,” Lewis said.

All JHU/JHMI and APL faculty, staff and students are invited to attend these free seminars designed to promote discussion and interaction with scientific and engineering professionals. To find out the location and to RSVP for each seminar, please contact Ashanti Edwards at ashanti@jhu.edu.

First annual NCI physical sciences-oncology center investigators’ meeting held

Bryan Smith (Stanford) and Christopher Hale (JHU) shared a PS-OC Young Investigators’ Trans Network Award. (Photo/Mary Spiro)

The First Annual Physical Sciences-Oncology Centers Network Investigators’ Meeting was held April 5-7, at the National Harbor in Washington, D.C. Johns Hopkins Engineering in Oncology Center director Denis Wirtz, professor of chemical and biomolecular engineering,  presented a tutorial on particle tracking, presented a talk on mechanobiology, and chaired a panel discussion on cancer cell mechanics.

In addition, several researchers affiliated with the EOC were awarded Young Investigators Trans-Network Project Awards. Wirtz’s doctoral student Christopher Hale, working with Bryan Smith of Stanford University, was recognized for the poster presentation “Tracking the Mechanics of Cancer in Living Subjects Using Intracellular Nanorheology.” Wirtz’s postdoctoral fellow Daniele Gilkes, working with colleagues at Cornell University, earned accolades for the poster presentation “Synergistic Effects of Hypoxia and Substrate Stiffness on Cancer Cell Force Generation.”

A total of 13 research posters from Johns Hopkins PS-OC were presented at the three-day meeting.

NanoBio Magazine premieres at INBT annual symposium

INBT launches new annual magazine.

As attendees arrived at the Johns Hopkins School of Public Health for the Institute for NanoBioTechnology’s (INBT) fourth annual symposium on April 29, they received the first edition of NanoBio Magazine. The new 32-page publication, which served as both the symposium program and as an attractive way to highlight some of INBT’s research in a more comprehensive way, will be published annually.

NanoBio Magazine, produced under the direction of INBT science writer Mary Spiro and INBT web director Martin Rietveld, showcases articles and photography about the institutes’s research, educational, corporate partnership and outreach programs. Articles were written by INBT staff, as well as students from the science communications course taught by Spiro each January during intersession. Photography came  from students who have participated in INBT supported educational programs, INBT staff, and from affiliated faculty members. The graphic design was created by Y.L. Media, LLC. of Baltimore.

“The magazine represents, in a creative and artistic way, the highly interdisciplinary spirit that is a fundamental mission of INBT,” Spiro said. “It was truly a collaborative effort that pulled content from our affiliated faculty and students  in every division and at every academic level that INBT serves. I hope people will learn what INBT is all about by reading it.”

Printed copies of NanoBio Magazine are available upon request by contacting Mary Spiro at mspiro@jhu.edu. Or, download a PDF version of NanoBio Magazine here:  nanobio-magazine_fordownload

Andrew Wong and Noah Tremblay peruse the first issue of NanoBio Magazine. (Photo by Charli Dvoracek/INBT)

INBT students to teach about self assembly during national science expo

USA Science and Engineering Festival, Oct 23-24

Predoctoral students, faculty and staff affiliated with INBT, including students in INBT’s National Science Foundation funded IGERT program, will help demonstrate the principles of self-assembly to children and adults alike. Participants at the INBT booth will be able to see at the macro scale what happens when materials of various shapes and sizes assemble into more complex structures at the nanoscale. Through a variety of hands-on experiments and by watching a variety of movies and animations about self assembly produced by the INBT Animation Studio, the students hope to be able to share their expertise in science and engineering with the general public.

During the two-day expo, USA Science and Engineering Festival organizers anticipate at least 750 exhibits from more than 350 of the nation’s leading science and engineering organizations including colleges and universities, corporations, federal agencies, museums and science centers, and professional engineering and science societies. Topics represented range from aerospace, green energy, medicine, biotechnology, climatology to robotics, nanotechnology, botany, neuroscience, genetics, and more.

The USA Science & Engineering Festival is the result of the highly successful inaugural San Diego Science FestivalSM held in April 2009 and both are the brainchild of life science and high technology entrepreneur Larry Bock. The festival is hosted by Lockheed Martin and sponsors include Life Technologies Foundation, Clean Technology and Sustainability Industries Organization (CTSI), Larry and Diane Bock, ResMed Foundation, Farrell Family Foundation, Alexandria Real Estate Equities, Northrop Grumman Corporation, Agilent Technologies, Amgen, Celgene Corporation, The Dow Chemical Company, National Institutes of Health, Illumina, You Can Do the Rubik’s Cube, Vertex Pharmaceuticals Inc., Genentech Inc., MedImmune, Sandia National Laboratories, Project Lead The Way (PLTW), K&L Gates, NuVasive Inc., FEI Company, Case Western Reserve University, Silicon Valley Bank, Bechtel Corporation, SpaceX and the National Radio Astronomy Observatory. Media partners include Popular Science and Science Illustrated, New Scientist, EE Times Group, SCIENTIFIC AMERICAN, POPULAR MECHANICS, Forbes Wolfe Emerging Tech Report, FAMILY Magazine and SciVee, Inc.

Additional Information:

Preview of the types of exhibits planned for the National Expo and view a short video of what happened in San Diego here.

For a complete list of sponsors, partners and exhibitors, click here.

EOC leader Gregg Semenza wins Canada Gairdner Award

Gregg Semenza

Gregg Semenza, associate director of Johns Hopkins Engineering in Oncology Center (EOC), has been named among seven 2010 winners of Canada’s international prize for medical research–the Canada Gairdner Award. The award is among the most prestigious for medical research and comes with a $100,000 cash prize.

The Canada Gairdner Award recognized Semenza for his work on how cells respond to oxygen availability in the body. He was the first to identify and describe hypoxia-inducible factor-1 (HIF-1), which switches genes on or off in response to oxygen levels.

Semenza leads a research project related to this topic for EOC with Sharon Gerecht, an assistant professor of chemical and biomolecular engineering. Their work focuses on analyzing the makeup and physical properties of the extracellular matrix, the three-dimensional scaffold in which cells live.

“Normal cells live in a flexible scaffold, but cancer cells create a rigid scaffold that they climb through to invade normal tissue,” Semenza said. “We will study how this change occurs and how it is affected by the amount of oxygen to which cancer cells are exposed. Our studies have shown that cancer cells are deprived of oxygen, which incites them to more aggressively invade the surrounding normal tissues where oxygen is more plentiful. Hypoxia-inducible factor 1 controls the responses of cancer cells to low oxygen, and we have recently identified drugs that block the action of HIF-1 and inhibit tumor growth in experimental cancer models.”

Semenza is the C. Michael Armstrong Professor in Medicine and founding director of the Vascular Biology program at  Johns Hopkins Institute for Cell Engineering at the School of Medicine. He also is a member of the McKusick-Nathans Institute of Genetic Medicine, is an affiliated faculty member of Johns Hopkins Institute for NanoBioTechnology, and has ties to the Department of Biological Chemistry and the Sidney Kimmel Comprehensive Cancer Center, both at the Johns Hopkins School of Medicine.

The Johns Hopkins Engineering in Oncology Center, launched October 2009, is one of 12 funded by the National Cancer Institute to bring a new cadre of theoretical physicists, mathematicians, chemists and engineers to the study of cancer. During the five-year initiative, the NCI’s Physical Sciences-Oncology Centers (PS-OC) will take new, nontraditional approaches to cancer research by studying the physical laws and principles of cancer; evolution and evolutionary theory of cancer; information coding, decoding, transfer and translation in cancer; and ways to deconvolute cancer’s complexity.

Read more about Gregg Semenza winning the Canada Gairdner Award in the Johns Hopkins Gazette story by Audrey Huang here.

Johns Hopkins Engineering in Oncology Center

Poster presenters needed for symposium on environmental, health impacts of nanotech

2009 INBT Poster Session (Photo: Jon Christofersen)

Poster titles are now being accepted for Johns Hopkins Institute for NanoBioTechnology’s fourth annual symposium, “Environmental and Health Impacts of Engineered Nanomaterials” set for Thursday, April 29, at the Bloomberg School of Public Health. Researchers from across the university, from government and industry, and from other universities are invited to submit posters by the deadline of April 22.

All students, faculty and staff affiliated with any Johns Hopkins campus or school may attend the symposium for free. Students from UMBC and Morgan State University may also attend at no cost.

This year’s symposium brings together faculty experts engaged in various aspects of nanotechnology risk assessment and management research. Jonathan Links, an INBT-affiliated professor in the Department of Environmental Health Sciences at the Bloomberg School, assembled the slate of speakers from across four divisions of the university.

Links said that this diversity reflects the multidisciplinary approach needed to effectively address questions of how nanomaterials move through and interact with the environment, and how they may impact biological organisms, including humans. Links added that despite some concerted efforts to assess risk, many questions remain unanswered about how engineered nanomaterials and nanoparticles impact human health and the environment.

“Without these data, we are flying blind. But when risk assessment is performed in tandem with research into beneficial applications, it helps researchers make better decisions about how nanotechnology is used in the future,” Links said.

Along with Links, professors from the Bloomberg School presenting talks at the symposium include Ellen Silbergeld, of Environmental Health Sciences, and Patrick Breysse, of Environmental Health Engineering and Environmental Health Sciences. William P. Ball, a professor in the Whiting School of Engineering’s Department of Geography and Environmental Engineering; Justin Hanes, a professor in the School of Medicine’s Department of Ophthalmology, with joint appointments in the Whiting School’s Department of Chemical and Biomolecular Engineering and the Bloomberg School’s Department of Environmental Health Sciences; and Howard Fairbrother, a professor in the Krieger School of Arts and Sciences’ Department of Chemistry, will talk about the transport of nanomaterials through environmental and biological systems, as well as the unusual properties of manufactured nanomaterials.

Tomas Guilarte, recently appointed chair of the Department of Environmental Health Sciences at Columbia University’s Mailman School of Public Health and a former professor at the Bloomberg School, will provide a presentation on neurotoxicity of nanoparticles. Ronald White, an associate scientist and deputy director of the Bloomberg School’s Risk Sciences and Public Policy Institute, will discuss policy implications based on risk assessment.

Symposium talks will be from 8:30 a.m. until noon in Sheldon Hall (W1214), and a poster session, with prizes for top presenters, will be held from 1:30 to 3 p.m. in Feinstone Hall (E2030).

To register for the symposium or to display a poster, click here.

For more information about INBT’s fourth annual symposium, click here.

Story by Mary Spiro