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The Role of Physical Cues in Collective Cell In Invasion

A hallmark of cancer is the spread, or metastasis, of cells from the tumor to distant tissues and organs. This project looks at how the physical forces exerted upon cancer cells by confinement within a tumor can regulate the migration of these cells, both collectively and alone.

Forces Involved in Collective Cell Migration

Pathologic and in vivo experimental evidence tells us that cancer cells like to travel in groups as they leave a tumor site and spread to other parts of the body. In this project, we investigate the forces involved in organizing the collective migration of breast cancer cells in both 2D and 3D environments.

Impact of Low Oxygen on the Migration of Sarcoma Cells

Low oxygen in a tumor (hypoxia) dramatically increases pulmonary metastasis and results in poor clinical outcomes. However, little is known about the effects of hypoxia on sarcoma cells and the microenvironment. In this project, we are learning how primary tumor cells respond to oxygen in their microenvironment.

News

Events

Oct
30
Fri
The 2020 Virtual Donald S. Coffey Prostate Research Day @ Virtual
Oct 30 @ 2:00 pm – 3:00 pm
The 2020 Virtual Donald S. Coffey Prostate Research Day @ Virtual

20th Annual William Wallace Scott Sr. Memorial Lecturship. Collaborating Across Disciplines for Prostate Cancer Discover and Translation with Elizabeth A. Platz, ScD, MPH

Elizabeth A. Platz, ScD, MPH Professor and Martin D. Abeloff, MD Scholar in Cancer Prevention, Professor of Epidemiology, Johns Hopkins Bloomberg, School of Public Health, Department of Urology, and the Sidney Kimmel Comprehensive Center at Johns Hopkins will be delivery the 20th Annual William Wallace Scott Sr. Memorial Lectureship. The title of her presentation is Collaborating across disciplines for prostate cancer discovery and translation.

Zoom link, meeting ID, and password available here. View the flyer here