The Role of Physical Cues in Collective Cell In Invasion

A hallmark of cancer is the spread, or metastasis, of cells from the tumor to distant tissues and organs. This project looks at how the physical forces exerted upon cancer cells by confinement within a tumor can regulate the migration of these cells, both collectively and alone.

Forces Involved in Collective Cell Migration

Pathologic and in vivo experimental evidence tells us that cancer cells like to travel in groups as they leave a tumor site and spread to other parts of the body. In this project, we investigate the forces involved in organizing the collective migration of breast cancer cells in both 2D and 3D environments.

Impact of Low Oxygen on the Migration of Sarcoma Cells

Low oxygen in a tumor (hypoxia) dramatically increases pulmonary metastasis and results in poor clinical outcomes. However, little is known about the effects of hypoxia on sarcoma cells and the microenvironment. In this project, we are learning how primary tumor cells respond to oxygen in their microenvironment.



Women in Cancer Research Seminar Series: Sarah Amend
Sep 24 @ 2:00 pm – 3:00 pm

Sarah Amend is an Assistant Professor, partnering with Dr. Ken Pienta to study the ecology of cancer.  She was a post-doctoral fellow in the lab and received her undergraduate degree from N.C. State University in Biological Sciences and did her Ph.D. thesis work on contributions of the microenvironment to bone resident cancer at Washington University in St. Louis. She is studying the role of the malignant cancer niche in inducing cancer cell biodiversity.

Location and details of the talk to come.