The Role of Physical Cues in Collective Cell In Invasion

A hallmark of cancer is the spread, or metastasis, of cells from the tumor to distant tissues and organs. This project looks at how the physical forces exerted upon cancer cells by confinement within a tumor can regulate the migration of these cells, both collectively and alone.

Forces Involved in Collective Cell Migration

Pathologic and in vivo experimental evidence tells us that cancer cells like to travel in groups as they leave a tumor site and spread to other parts of the body. In this project, we investigate the forces involved in organizing the collective migration of breast cancer cells in both 2D and 3D environments.

Impact of Low Oxygen on the Migration of Sarcoma Cells

Low oxygen in a tumor (hypoxia) dramatically increases pulmonary metastasis and results in poor clinical outcomes. However, little is known about the effects of hypoxia on sarcoma cells and the microenvironment. In this project, we are learning how primary tumor cells respond to oxygen in their microenvironment.

News

February 18, 2019

The latest edition of the Nano-Bio Report reveals the exciting developments from 2018 to strengthen INBT’s platforms in research, education,... Read More

Events

Jun
26
Wed
Summer Seminar Series – Michael Tsapatsis @ Shaffer Hall 2, JHU Homewood Campus
Jun 26 @ 12:00 pm – 1:00 pm
Summer Seminar Series - Michael Tsapatsis @ Shaffer Hall 2, JHU Homewood Campus

Zeolites are microporous framework silicates that are used widely in the chemical industry as heterogeneous acid catalysts, efficient ion exchangers, selective adsorbents for gas separations and as perm-selective dehydration membranes. They are also useful in other applications like water softening, as desiccants, and for adsorptive/catalytic treatment of automotive emissions. Zeolites have a wide range of compositions, and Dr. Tsapatsis’ will focus his talk on pure silica zeolites (zeosils) and high silica zeolites, i.e., zeolites with large ratio of silicon to substituents like Al, B, Ge, Sn, Ti that isomorphously replace silicon in the tetrahedral sites of the zeolite framework.

Michael Tsapatsis’ research group and collaborators have devoted more than two decades to study zeolite nucleation and crystal growth in efforts to create (i) nanometer-thin, oriented, and pinhole-free separation membranes, and (ii) hierarchical porous adsorbents and catalysts.

The Summer Seminar Series is co-sponsored by PS-OC and the Institute for NanoBioTechnology.

Jul
1
Mon
Summer Seminar Series – Christopher Jewell @ Shaffer Hall 300, JHU Homewood Campus
Jul 1 @ 12:00 pm – 1:00 pm
Summer Seminar Series - Christopher Jewell @ Shaffer Hall 300, JHU Homewood Campus

Details about Christopher Jewell’s talk to come.

The Summer Seminar Series is co-sponsored by the PS-OC and the Institute for NanoBioTechnology.

Jul
15
Mon
Summer Seminar Series – Warren Grayson @ Shaffer Hall 2, JHU Homewood Campus
Jul 15 @ 12:00 pm – 1:00 pm
Summer Seminar Series - Warren Grayson @ Shaffer Hall 2, JHU Homewood Campus

Details on Warren Grayson’s talk to come.

The Summer Seminar Series is co-sponsored by the PS-OC and Institute for NanoBioTechnology.