The Role of Physical Cues in Collective Cell In Invasion

A hallmark of cancer is the spread, or metastasis, of cells from the tumor to distant tissues and organs. This project looks at how the physical forces exerted upon cancer cells by confinement within a tumor can regulate the migration of these cells, both collectively and alone.

Forces Involved in Collective Cell Migration

Pathologic and in vivo experimental evidence tells us that cancer cells like to travel in groups as they leave a tumor site and spread to other parts of the body. In this project, we investigate the forces involved in organizing the collective migration of breast cancer cells in both 2D and 3D environments.

Impact of Low Oxygen on the Migration of Sarcoma Cells

Low oxygen in a tumor (hypoxia) dramatically increases pulmonary metastasis and results in poor clinical outcomes. However, little is known about the effects of hypoxia on sarcoma cells and the microenvironment. In this project, we are learning how primary tumor cells respond to oxygen in their microenvironment.

News

Events

Sep
24
Tue
Women in Cancer Research Fall Mini Seminar Series: Sarah Amend @ Croft Hall G40, JHU Homewood campus
Sep 24 @ 2:00 pm – 3:00 pm
Women in Cancer Research Fall Mini Seminar Series: Sarah Amend @ Croft Hall G40, JHU Homewood campus

“Ecology Meets Cancer Biology: Keystone Cancer Cells are Actuators of Therapy Resistance and Cancer Lethality”

Using cancer ecology to solve the problem of metastasis, Amend’s research is focused on understanding the role of the tumor microenvironment in cancer progression, specifically related to lethal metastasis.

Sarah Amend is an Assistant Professor, partnering with Dr. Ken Pienta to study the ecology of cancer.  She was a post-doctoral fellow in the lab and received her undergraduate degree from N.C. State University in Biological Sciences and did her Ph.D. thesis work on contributions of the microenvironment to bone resident cancer at Washington University in St. Louis. She is studying the role of the malignant cancer niche in inducing cancer cell biodiversity.

 

Oct
29
Tue
Women in Cancer Research Fall Mini-Seminar Series: Aikaterini Kontrogianni-Konstantopoulos @ Croft Hall G40, JHU Homewood campus
Oct 29 @ 2:00 pm – 3:00 pm
Women in Cancer Research Fall Mini-Seminar Series: Aikaterini Kontrogianni-Konstantopoulos @ Croft Hall G40, JHU Homewood campus

Aikaterini Kontrogianni-Konstantopoulos research focuses on the elucidation of the roles of cytoskeletal and membrane-associated proteins as structural and signaling mediators. Using the muscle and epithelial cell as model systems, my laboratory has pioneered the molecular and functional characterization of the obscurin subfamily and its binding partner Myosin Binding Protein-C slow in health and disease.

In 2007, she joined the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine as Assistant Professor in the tenure track. Using the muscle and epithelial cell as model systems, her laboratory has pioneered the molecular and functional characterization of major cytoskeletal and membrane-associated proteins as structural and signaling mediators in health and disease.

Nov
5
Tue
Women in Cancer Research Fall Mini Seminar Series: Efronsini “Efie” Kokkoli @ Croft Hall G40, JHU Homewood campus
Nov 5 @ 2:43 pm – 3:43 pm
Women in Cancer Research Fall Mini Seminar Series: Efronsini "Efie" Kokkoli @ Croft Hall G40, JHU Homewood campus

Efie Kokkoli, a targeted drug delivery specialist, is a professor in the Chemical and Biomolecular Department at the Whiting School of Engineering. Her research focuses on the areas of DNA nanotechnology, multi-targeted gene and drug delivery, and the design of biopolymers and responsive hydrogels. With the goal of directing nanoparticles capable of carrying cancer drugs to tumor sites while sparing non-cancerous areas, her group concentrates on designing biomaterials ranging from polymeric nanoparticles to DNA nanotubes that respond best under certain conditions, like temperature or pH, and have specificity for cancer cells.