Publications

Books

Biomechanics in Oncology
Edited by Cheng Dong, Nastaran Zahir, and Konstantinos Konstantopoulos
Published by Springer Nature Switzerland AG, 2018.

Hypoxia and Cancer Metastasis
Edited by Daniele Gilkes
Springer Nature International Publishing, 2019

Modern Mechanobiology: Convergence of Development and Genomics
Edited by Tzung K. Hsiai, Sharon Gerecht, Juhyun Lee, and Hanjoong Jo
Published by Jenny Stanford Publishing, coming December 2020

Journal Publications

2021

Joe NS, Hodgdon C, Kraemer L, Redmond KJ, Stearns V, Gilkes DM. A common goal to CARE: Cancer Advocates, Researchers, and Clinicians Explore current treatments and clinical trials for breast cancer brain metastases. NPJ Breast Cancer. 2021 Sep 14;7(1):121. doi: 10.1038/s41523-021-00326-5. PMID: 34521857.
Heber L. Rocha, Inês Godet, Furkan Kurtoglu, John Metzcar, Kali Konstantinopoulos, Soumitra Bhoyar, Daniele M. Gilkes, Paul Macklin, A persistent invasive phenotype in post-hypoxic tumor cells is revealed by fate mapping and computational modeling, iScience, Volume 24, Issue 9, 2021, 102935, ISSN 2589-0042, doi.org/10.1016/j.isci.2021.102935.

2020

P.H. Wu, S.S. Gambhir*, C.M. Hale, W.C. Chen, D. Wirtz*, B.R. Smith*, “Monitoring nanomechanics of tumor progression in living subjects at single-cell resolution”, (in press) Materials Today
Ye S, Liu Y, Fuller AM, Katti R, Ciotti GE, Chor S, Alam MZ, Devalaraja S, Lorent K, Weber K, Haldar M, Pack MA, Eisinger-Mathason TSK. TGFβ and Hippo Pathways Cooperate to Enhance Sarcomagenesis and Metastasis through the Hyaluronan-Mediated Motility Receptor (HMMR). Mol Cancer Res. 2020 Jan 27;. doi: 10.1158/1541-7786.MCR-19-0877. [Epub ahead of print] PubMed PMID: 31988250
Wu PH, Gilkes DM, Phillip JM, Narkar A, Cheng TW, Marchand J, Lee MH, Li R, Wirtz D. Single-cell morphology encodes metastatic potential. Sci Adv. 2020 Jan;6(4):eaaw6938. doi: 10.1126/sciadv.aaw6938. eCollection 2020 Jan.

2019

Li Y, Yao L, Mori Y, Sun SX. On the energy efficiency of cell migration in diverse physical environments. Proc Natl Acad Sci U S A. 2019 Nov 12;. doi: 10.1073/pnas.1907625116
Mistriotis P, Wisniewski EO, Bera K, Keys J, Li Y, Tuntithavornwat S, Law RA, Perez-Gonzalez NA, Erdogmus E, Zhang Y, Zhao R, Sun SX, Kalab P, Lammerding J, Konstantopoulos K. Confinement hinders motility by inducing RhoA-mediated nuclear influx, volume expansion, and blebbing. J Cell Biol. 2019 Nov 5;. doi: 10.1083/jcb.201902057. [Epub ahead of print] PubMed PMID: 31690619
Godet I, Shin YJ, Ju JA, Ye IC, Wang G, Gilkes DM. Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis. Nat Commun. 2019 Oct 24;10(1):4862. doi: 10.1038/s41467-019-12412-1.
Perez-Gonzalez NA, Rochman ND, Yao K, Tao J, Le MT, Flanary S, Sablich L, Toler B, Crentsil E, Takaesu F, Lambrus B, Huang J, Fu V, Chengappa P, Jones TM, Holland AJ, An S, Wirtz D, Petrie RJ, Guan KL, Sun SX. YAP and TAZ regulate cell volume. J Cell Biol. 2019 Oct 7;218(10):3472-3488. doi: 10.1083/jcb.201902067. Epub 2019 Sep 3.
Padmanaban V, Krol I, Suhail Y, Szczerba BM, Aceto N, Bader JS, Ewald AJ. E-cadherin is required for metastasis in multiple models of breast cancer. Nature. 2019 Sep;573(7774):439-444. doi: 10.1038/s41586-019-1526-3. Epub 2019 Sep 4.
Georgess D, Padmanaban V, Sirka OK, Coutinho K, Choi A, Frid G, Neumann NM, Inoue T, Ewald AJ. Twist1-induced epithelial dissemination requires Prkd1 signaling. Cancer Res. 2019 Nov 1;. doi: 10.1158/0008-5472.CAN-18-3241. [Epub ahead of print]
Yankaskas CL, Thompson KN, Paul CD, Vitolo MI, Mistriotis P, Mahendra A, Bajpai VK, Shea DJ, Manto KM, Chai AC, Varadarajan N, Kontrogianni-Konstantopoulos A, Martin SS, Konstantopoulos K. A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens. Nat Biomed Eng. 2019 Jun;3(6):452-465. doi: 10.1038/s41551-019-0400-9. Epub 2019 May 6. PubMed PMID: 31061459.
Wong BS, Shea DJ, Mistriotis P, Tuntithavornwat S, Law RA, Bieber JM, Zheng L, Konstantopoulos K. A Direct Podocalyxin-Dynamin-2 Interaction Regulates Cytoskeletal Dynamics to Promote Migration and Metastasis in Pancreatic Cancer Cells. Cancer Res. 2019 Jun 1;79(11):2878-2891. doi: 10.1158/0008-5472.CAN-18-3369. Epub 2019 Apr 11. PubMed PMID: 30975647; PubMed Central PMCID: PMC6548656.
Bayer SV, Grither WR, Brenot A, Hwang PY, Barcus CE, Ernst M, Pence P, Walter C, Pathak A, Longmore GD. DDR2 controls breast tumor stiffness and metastasis by regulating Integrin mediated mechanotransduction in CAFs. Elife. 2019 May 30;8. doi: 10.7554/eLife.45508. [Epub ahead of print] PubMed PMID: 31144616.
Zhao R, Afthinos A, Zhu T, Mistriotis P, Li Y, Serra SA, Zhang Y, Yankaskas CL, He S, Valverde MA, Sun SX, Konstantopoulos K. Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area. Sci Adv. 2019 Jul;5(7):eaaw7243. doi: 10.1126/sciadv.aaw7243.
Gilkes DM, Wirtz D. Solid Stress in Brain Tumors. Trends Cancer. 2019 May;5(5):266-268. doi: 10.1016/j.trecan.2019.03.003. Epub 2019 Apr 8. PubMed PMID: 31174838.
Hwang PY, Brenot A, King AC, Longmore GD, George SC. Randomly Distributed K14⁺Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues. Cancer Res. 2019 Apr 15;79(8):1899-1912. doi: 10.1158/0008-5472.CAN-18-2828. Epub 2019 Mar 12. PubMed PMID: 30862718; PubMed Central PMCID: PMC6467777.
Lewis DM, Pruitt H, Jain N, Ciccaglione M, McCaffery JM, Xia Z, Weber K, Eisinger-Mathason TSK, Gerecht S. A Feedback Loop between Hypoxia and Matrix Stress Relaxation Increases Oxygen-Axis Migration and Metastasis in Sarcoma. Cancer Res. 2019 Apr 15;79(8):1981-1995. doi: 10.1158/0008-5472.CAN-18-1984. Epub 2019 Feb 18. PubMed PMID: 30777851.
Hickey JW, Dong Y, Chung JW, Salathe SF, Pruitt HC, Li X, Chang C, Fraser AK, Bessell CA, Ewald AJ, Gerecht S, Mao HQ, Schneck JP. Engineering an Artificial T-Cell Stimulating Matrix for Immunotherapy. Adv Mater. 2019 Apr 10;:e1807359. doi: 10.1002/adma.201807359. [Epub ahead of print] PubMed PMID: 30968468.
Nair PR, Wirtz D. Enabling migration by moderation: YAP/TAZ are essential for persistent migration. J Cell Biol. 2019 Apr 1;218(4):1092-1093. doi: 10.1083/jcb.201902035. Epub 2019 Mar 14. PubMed PMID: 30872360; PubMed Central PMCID: PMC6446847.
Blatchley MR, Hall F, Wang S, Pruitt HC, Gerecht S. Hypoxia and matrix viscoelasticity sequentially regulate endothelial progenitor cluster-based vasculogenesis. Sci Adv. 2019 Mar;5(3):eaau7518. doi: 10.1126/sciadv.aau7518. eCollection 2019 Mar. PubMed PMID: 30906859; PubMed Central PMCID: PMC6426463.
Pruitt HC, Lewis D, Ciccaglione M, Connor S, Smith Q, Hickey JW, Schneck JP, Gerecht S. Collagen fiber structure guides 3D motility of cytotoxic T lymphocytes. Matrix Biol. 2019 Feb 16;. doi: 10.1016/j.matbio.2019.02.003. [Epub ahead of print] PubMed PMID: 30776427.
Xiang L, Gilkes DM. The Contribution of the Immune System in Bone Metastasis Pathogenesis. Int J Mol Sci. 2019 Feb 25;20(4). doi: 10.3390/ijms20040999. Review. PubMed PMID: 30823602; PubMed Central PMCID: PMC6412551.
Li L, Knutsdottir H, Hui K, Weiss MJ, He J, Philosophe B, Cameron AM, Wolfgang CL, Pawlik TM, Ghiaur G, Ewald AJ, Mezey E, Bader JS, Selaru FM. Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity. JCI Insight. 2019 Jan 24;4(2). doi: 10.1172/jci.insight.121490. [Epub ahead of print] PubMed PMID: 30674722; PubMed Central PMCID: PMC6413833.

2018

Bhoyar S, Godet I, DiGiacomo JW, Gilkes DM. A software tool for the quantification of metastatic colony growth dynamics and size distributions in vitro and in vivo. PLoS One. 2018;13(12):e0209591. doi: 10.1371/journal.pone.0209591. eCollection 2018. PubMed PMID: 30589908; PubMed Central PMCID: PMC6307751
Wei Z, Gerecht S. A self-healing hydrogel as an injectable instructive carrier for cellular morphogenesis. Biomaterials. 2018 Dec;185:86-96. doi: 10.1016/j.biomaterials.2018.09.003. Epub 2018 Sep 7. PubMed PMID: 30236839; PubMed Central PMCID: PMC6432635.
Ye IC, Fertig EJ, DiGiacomo JW, Considine M, Godet I, Gilkes DM. Molecular Portrait of Hypoxia in Breast Cancer: A Prognostic Signature and Novel HIF-Regulated Genes. Mol Cancer Res. 2018 Dec;16(12):1889-1901. doi: 10.1158/1541-7786.MCR-18-0345. Epub 2018 Jul 23. PubMed PMID: 30037853; PubMed Central PMCID: PMC6279594.
Harris MJ, Wirtz D, Wu PH. Dissecting cellular mechanics: Implications for aging, cancer, and immunity. Semin Cell Dev Biol. 2018 Oct 30;. doi: 10.1016/j.semcdb.2018.10.008. [Epub ahead of print] Review. PubMed PMID: 30359779.
Kim DH, Ewald AJ, Park J, Kshitiz, Kwak M, Gray RS, Su CY, Seo J, An SS, Levchenko A.Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread. Sci Rep. 2018 Sep 21;8(1):14210. doi: 10.1038/s41598-018-32010-3. PubMed PMID: 30242256; PubMed Central PMCID: PMC6155084.
Liu X, Cheng Y, Abraham JM, Wang Z, Wang Z, Ke X, Yan R, Shin EJ, Ngamruengphong S, Khashab MA, Zhang G, McNamara G, Ewald AJ, Lin D, Liu Z, Meltzer SJ. Modeling Wnt signaling by CRISPR-Cas9 genome editing recapitulates neoplasia in human Barrett epithelial organoids. Cancer Lett. 2018 Nov 1;436:109-118. doi: 10.1016/j.canlet.2018.08.017. Epub 2018 Aug 23. PubMed PMID: 30144514; PubMed Central PMCID: PMC6152930.
Gomes CJ, Harman MW, Centuori SM, Wolgemuth CW, Martinez JD. Measuring DNA content in live cells by fluorescence microscopy. Cell Div. 2018;13:6. doi: 10.1186/s13008-018-0039-z. eCollection 2018. PubMed PMID: 30202427; PubMed Central PMCID: PMC6123973.
Sirka OK, Shamir ER, Ewald AJ. Myoepithelial cells are a dynamic barrier to epithelial dissemination. J Cell Biol. 2018 Oct 1;217(10):3368-3381. doi: 10.1083/jcb.201802144. Epub 2018 Jul 30. PubMed PMID: 30061105; PubMed Central PMCID: PMC6168248
Grither WR, Longmore GD. Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7786-E7794. doi: 10.1073/pnas.1805020115. Epub 2018 Jul 30. PubMed PMID: 30061414; PubMed Central PMCID: PMC6099886.
Smith Q, Macklin B, Chan XY, Jones H, Trempel M, Yoder MC, Gerecht S.Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells. Cell Rep. 2018 Jul 24;24(4):895-908.e6. doi: 10.1016/j.celrep.2018.06.083. PubMed PMID: 30044986
Lewis DM, Mavrogiannis N, Gagnon Z, Gerecht S. Microfluidic platform for the real time measurement and observation of endothelial barrier function under shear stress. Biomicrofluidics. 2018 Jul;12(4):042202. doi: 10.1063/1.5026901. eCollection 2018 Jul. PubMed PMID: 29861813; PubMed Central PMCID: PMC5953754.
Wu PH, Aroush DR, Asnacios A, Chen WC, Dokukin ME, Doss BL, Durand-Smet P, Ekpenyong A, Guck J, Guz NV, Janmey PA, Lee JSH, Moore NM, Ott A, Poh YC, Ros R, Sander M, Sokolov I, Staunton JR, Wang N, Whyte G, Wirtz D. A comparison of methods to assess cell mechanical properties. Nat Methods. 2018 Jul;15(7):491-498. doi: 10.1038/s41592-018-0015-1. Epub 2018 Jun 18. PubMed PMID: 29915189.
Wu, PH, Gilkes GM, Wirtz D. The Biophysics of 3D Cell Migration. Annual Reviews of Biophysics. 2018 May; (47) 549-567. doi.org/10.1146/annurev-biophys-070816-033854.
Neumann NM, Perrone MC, Veldhuis JH, Huebner RJ, Zhan H, Devreotes PN, Brodland GW, Ewald AJ. Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation. Dev Cell. 2018 Apr 9;45(1):67-82.e6. doi: 10.1016/j.devcel.2018.03.011. PubMed PMID: 29634937; PubMed Central PMCID: PMC5983037.
DiGiacomo JW, Gilkes DM. Tumor Hypoxia As an Enhancer of Inflammation-Mediated Metastasis: Emerging Therapeutic Strategies. Target Oncol. 2018 Apr;13(2):157-173. doi: 10.1007/s11523-018-0555-4. PubMed PMID: 29423593.
Rochman ND, Popescu DM, Sun SX. Ergodicity, hidden bias and the growth rate gain. Phys Biol. 2018 Mar 14;15(3):036006. doi: 10.1088/1478-3975/aab0e6. PubMed PMID: 29461250; PubMed Central PMCID: PMC5922272.
Pardo-Pastor C, Rubio-Moscardo F, Vogel-González M, Serra SA, Afthinos A, Mrkonjic S, Destaing O, Abenza JF, Fernández-Fernández JM, Trepat X, Albiges-Rizo C, Konstantopoulos K, Valverde MA. Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses. Proc Natl Acad Sci U S A.2018 Feb 20;115(8):1925-1930. doi: 10.1073/pnas.1718177115. Epub 2018 Feb 5. PubMed PMID: 29432180; PubMed Central PMCID: PMC5828612.
Ju JA, Gilkes DM. RhoB: Team Oncogene or Team Tumor Suppressor?. Genes (Basel). 2018 Jan 30;9(2). doi: 10.3390/genes9020067. Review. PubMed PMID: 29385717; PubMed Central PMCID: PMC5852563.
Wong BS, Mistriotis P, Konstantopoulos K. Exposing Cell-Itary Confinement: Understanding the Mechanisms of Confined Single Cell Migration. Adv Exp Med Biol.2018;1092:139-157. doi: 10.1007/978-3-319-95294-9_8. PubMed PMID: 30368752.
select

Belcher DA, Ju JA, Baek JH, Yalamanoglu A, Buehler PW, Gilkes DM, Palmer AF. The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study. PLoS One.2018;13(2):e0191275. doi: 10.1371/journal.pone.0191275. eCollection 2018. PubMed PMID: 29414985; PubMed Central PMCID: PMC5802857
Ju JA, Gilkes DM. RhoB: Team Oncogene or Team Tumor Suppressor?. Genes (Basel).2018 Jan 30;9(2). doi: 10.3390/genes9020067. Review. PubMed PMID: 29385717; PubMed Central PMCID: PMC5852563.

2017

Koons B, Sharma P, Ye Z, Mukherjee A, Lee MH, Wirtz D, Behkam B, Nain AS.Cancer Protrusions on a Tightrope: Nanofiber Curvature Contrast Quantitates Single Protrusion Dynamics. ACS Nano. 2017 Dec 26;11(12):12037-12048. doi: 10.1021/acsnano.7b04567. Epub 2017 Dec 1. PubMed PMID: 29144730.
Li Y, He L, Gonzalez NAP, Graham J, Wolgemuth C, Wirtz D, Sun SX. Going with the Flow: Water Flux and Cell Shape during Cytokinesis. Biophys J. 2017 Dec 5;113(11):2487-2495. doi: 10.1016/j.bpj.2017.09.026. PubMed PMID: 29212002; PubMed Central PMCID: PMC5738528.
Asrani K, Sood A, Torres A, Georgess D, Phatak P, Kaur H, Dubin A, Talbot CC Jr, Elhelu L, Ewald AJ, Xiao B, Worley P, Lotan TL. mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation. J Clin Invest. 2017 Nov 1;127(11):4001-4017. doi: 10.1172/JCI92893. Epub 2017 Sep 25. PubMed PMID: 28945203; PubMed Central PMCID: PMC5663351.
Nasrollahi S, Walter C, Loza AJ, Schimizzi GV, Longmore GD, Pathak A. Past matrix stiffness primes epithelial cells and regulates their future collective migration through a mechanical memory. Biomaterials. 2017 Nov;146:146-155. doi: 10.1016/j.biomaterials.2017.09.012. Epub 2017 Sep 8. PubMed PMID: 28918264; PubMed Central PMCID: PMC5659718.
Gomes CJ, Centuori SM, Harman MW, Putnam CW, Wolgemuth CW, Martinez JD. The induction of endoreduplication and polyploidy by elevated expression of 14-3-3γ. Genes Cancer. 2017 Nov;8(11-12):771-783. doi: 10.18632/genesandcancer.161. PubMed PMID: 29321819; PubMed Central PMCID: PMC5755723.
Vig DK, Hamby AE, Wolgemuth CW. Cellular Contraction Can Drive Rapid Epithelial Flows. Biophys J. 2017 Oct 3;113(7):1613-1622. doi: 10.1016/j.bpj.2017.08.004. PubMed PMID: 28978451; PubMed Central PMCID: PMC5627147.
Sewell-Loftin MK, Bayer SVH, Crist E, Hughes T, Joison SM, Longmore GD, George SC. Cancer-associated fibroblasts support vascular growth through mechanical force. Sci Rep. 2017 Oct 3;7(1):12574. doi: 10.1038/s41598-017-13006-x. PubMed PMID: 28974764; PubMed Central PMCID: PMC5626692.
Yochum ZA, Cades J, Mazzacurati L, Neumann NM, Khetarpal SK, Chatterjee S, Wang H, Attar MA, Huang EH, Chatley SN, Nugent K, Somasundaram A, Engh JA, Ewald AJ, Cho YJ, Rudin CM, Tran PT, Burns TF. A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer. Mol Cancer Res. 2017 Dec;15(12):1764-1776. doi: 10.1158/1541-7786.MCR-17-0298. Epub 2017 Aug 29. PubMed PMID: 28851812; PubMed Central PMCID: PMC5712248.
Nguyen-Ngoc KV, Silvestri VL, Georgess D, Fairchild AN, Ewald AJ. Mosaic loss of non-muscle myosin IIA and IIB is sufficient to induce mammary epithelial proliferation. J Cell Sci. 2017 Oct 1;130(19):3213-3221. doi: 10.1242/jcs.208546. Epub 2017 Aug 18. PubMed PMID: 28821574; PubMed Central PMCID: PMC5665442.
Lewis DM, Blatchley MR, Park KM, Gerecht S. O₂-controllable hydrogels for studying cellular responses to hypoxic gradients in three dimensions in vitro and in vivo. Nat Protoc. 2017 Aug;12(8):1620-1638. doi: 10.1038/nprot.2017.059. Epub 2017 Jul 20. PubMed PMID: 28726849; PubMed Central PMCID: PMC5965277.
Haffner MC, Esopi DM, Chaux A, Gürel M, Ghosh S, Vaghasia AM, Tsai H, Kim K, Castagna N, Lam H, Hicks J, Wyhs N, Biswal Shinohara D, Hurley PJ, Simons BW, Schaeffer EM, Lotan TL, Isaacs WB, Netto GJ, De Marzo AM, Nelson WG, An SS, Yegnasubramanian S. AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination. Nat Commun. 2017 Jul 26;8(1):142. doi: 10.1038/s41467-017-00084-8. PubMed PMID: 28747635; PubMed Central PMCID: PMC5529512.
Ju JA, Godet I, Ye IC, Byun J, Jayatilaka H, Lee SJ, Xiang L, Samanta D, Lee MH, Wu PH, Wirtz D, Semenza GL, Gilkes DM. Hypoxia Selectively Enhances Integrin α₅β₁ Receptor Expression in Breast Cancer to Promote Metastasis. Mol Cancer Res. 2017 Jun;15(6):723-734. doi: 10.1158/1541-7786.MCR-16-0338. Epub 2017 Feb 17. PubMed PMID: 28213554; PubMed Central PMCID: PMC5510543.
Jayatilaka H, Tyle P, Chen JJ, Kwak M, Ju J, Kim HJ, Lee JSH, Wu PH, Gilkes DM, Fan R, Wirtz D. Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration. Nat Commun. 2017 May 26;8:15584. doi: 10.1038/ncomms15584. PubMed PMID: 28548090; PubMed Central PMCID: PMC5458548.
Tao J, Li Y, Vig DK, Sun SX. Cell mechanics: a dialogue. Rep Prog Phys. 2017 Mar;80(3):036601. doi: 10.1088/1361-6633/aa5282. Epub 2017 Jan 27. Review. PubMed PMID: 28129208; PubMed Central PMCID: PMC5518794.
Ahmadzadeh H, Webster MR, Behera R, Jimenez Valencia AM, Wirtz D, Weeraratna AT, Shenoy VB. Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1617-E1626. doi: 10.1073/pnas.1617037114. Epub 2017 Feb 14. PubMed PMID: 28196892; PubMed Central PMCID: PMC5338523.

2016

Paul CD, Mistriotis P, Konstantopoulos K. Cancer cell motility: lessons from migration in confined spaces. Nat Rev Cancer. 2017 Feb;17(2):131-140. doi: 10.1038/nrc.2016.123. Epub 2016 Dec 2. Review. PubMed PMID: 27909339; PubMed Central PMCID: PMC5364498.
Lindberg OR, McKinney A, Engler JR, Koshkakaryan G, Gong H, Robinson AE, Ewald AJ, Huillard E, David James C, Molinaro AM, Shieh JT, Phillips JJ. GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity. Oncotarget.2016 Nov 29;7(48):79101-79116. doi: 10.18632/oncotarget.12600. PubMed PMID: 27738329; PubMed Central PMCID: PMC5346701.
Loza AJ, Koride S, Schimizzi GV, Li B, Sun SX, Longmore GD. Cell density and actomyosin contractility control the organization of migrating collectives within an epithelium. Mol Biol Cell. 2016 Nov 7;27(22):3459-3470. doi: 10.1091/mbc.E16-05-0329. Epub 2016 Sep 7. PubMed PMID: 27605707; PubMed Central PMCID: PMC5221580.
Shah MY, Martinez-Garcia E, Phillip JM, Chambliss AB, Popovic R, Ezponda T, Small EC, Will C, Phillip MP, Neri P, Bahlis NJ, Wirtz D, Licht JD. MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents. Oncogene. 2016 Nov 10;35(45):5905-5915. doi: 10.1038/onc.2016.116. Epub 2016 Apr 25. PubMed PMID: 27109101; PubMed Central PMCID: PMC6071667.
Lee P, Wolgemuth CW. Physical Mechanisms of Cancer in the Transition to Metastasis. Biophys J. 2016 Jul 12;111(1):256-66. doi: 10.1016/j.bpj.2016.05.046. PubMed PMID: 27410752; PubMed Central PMCID: PMC4944793.