cancer diagnostics DREAMing A simple and cost-effective method for detecting, analyzing and enumerating rare, heterogeneously-methlyated epialleles in complex samples such as liquid biopsies. HYPER-Melt A low-cost digital microfluidic platform for analyzing DNA methylation with an unprecedented combination of sensitivity, specificity and resolution. EpiClass A computational method for leveraging single-molecule methylation density data to improve the performance of methylation biomarkers for cancer diagnostics. cancer biology & biomarker discovery Methylation in ovarian cancer Genome-wide methylation analysis and selective bioinformatic criteria identify a panel of highly-specific methylation biomarkers for potential use in the diagnosis of ovarian cancer. HGSC precursor methylation Methylomic analyses show that fallopian tube precursor lesions are epigenetically similar to high-grade serous carcinomas and identify methylation biomarkers with potential use for early detection. LINE-1 deregulation in HGSC precursors LINE-1 retrotransposons become epigenetically deregulated during the progression of ovarian cancer precursor lesions.
