Jamie Spangler earned a Bachelor of Science degree in Biomedical Engineering at Johns Hopkins University and a PhD in Biological Engineering at MIT. She then conducted postdoctoral research in the Molecular & Cellular Physiology and Structural Biology departments at Stanford University School of Medicine before launching her independent research group at Johns Hopkins University in July 2017, jointly between the departments of Biomedical Engineering and Chemical & Biomolecular Engineering.
Her lab, located in the Translational Tissue Engineering Center at the School of Medicine, applies structural and mechanistic insights to re-engineer existing proteins and design new proteins that therapeutically modulate the immune response. In particular, her group is interested in engineering immune molecules such as antibodies and cytokines for targeted treatment of diseases such as cancer and autoimmune disorders. Leveraging cutting-edge tools and exclusive expertise in structural biology and molecular design, the Spangler lab implements a unique structure-based engineering approach to elucidate the determinants of protein activity in order to inform protein therapeutic development.