What’s on the horizon for regenerative medicine?

Organo-electric nanowires.  (Tovar Lab/JHU)

Organo-electric nanowires. (Tovar Lab/JHU)

Editor’s Note: The following is a summary of one of the talks from the 2013 Nano-bio Symposium hosted by Johns Hopkins Institute for NanoBioTechnology held May 17. This summary was written by Christian Pick, a doctoral candidate in the chemical and biomolecular engineering laboratory of Joelle Frechette. Look for other symposium summaries on the INBT blog.

The fundamental goal of regenerative medicine is to allow the body to restore normal function to damaged or diseased tissues. Tissue scaffolds provide a structure for cells to grow on to accomplish this task. The pinnacle of scaffold function would be for the tissue grown from a scaffold to be completely indistinguishable from natural, undamaged tissue.

In order to improve scaffolds, researchers need to better understand how scaffolds interact with the body. Peter Gabriele, Director of Emerging Technology at Secant Medical, discussed FT-IR microscopy,  which is a unique tool that can help researchers with this very task.

Fourier transform infrared (FTIR) spectroscopy is a powerful technique for analyzing the chemical identity of materials. FTIR spectroscopy has been used for years in forensic analysis for identifying unknown samples. FTIR microscopy combines the functionality of FTIR spectroscopy with optical microscopy.

For the field of regenerative medicine, this means that the surface functionality of a scaffold can be mapped and studied throughout its entire lifetime: from production through degradation in-vivo. For instance, FTIR microscopy can be used to analyze surface modifications made to a scaffold during fabrication.

Additionally, it can be used to track tissue formation in implanted scaffolds. As an example, Mr. Gabriele described studies on “biorubber” or poly(glycerol sebacate) (PGS). FTIR microscopy has been used to identify collagen integration within the polymer during implantation as well as map the erosion of the material once implanted. Through the use of tools such as FT-IR microscopy, researchers can continue to expand the functionality of tissue scaffolds.

Secant Medical

Watch a video about INBT’s current research efforts in the realm of regenerative medicine here.

Regenerative medicine theme of science-writer bootcamp

Screen Shot 2013-04-01 at 3.19.05 PMJohns Hopkins invites you to the fifth annual science-writer boot camp. This year’s topic will be Regenerative Medicine. Join Johns Hopkins experts in regenerative medicine to learn the latest in stem cell research, tissue regeneration and organ transplantation.

Three of the 11 presenters are affiliated faculty members of the Johns Hopkins Institute for NanoBioTechnology. This event is sponsored by the Johns Hopkins Institute for Basic Biomedical Sciences.  There is no cost but reservations are required. Working press as well as freelance writers are invited to attend.

WHAT: Body Building: Recent Advances in Regenerative Medicine

WHEN: Monday, April 29, 2011, 9 a.m. to 4 p.m. (lunch will be provided)

WHERE: Bernstein-Offit Building, room LL7, Johns Hopkins SAIS Campus, 1717 Massachusetts Ave., NW, Washington, D.C. 20036

RSVP: Vanessa McMains at vmcmain1@jhmi.edu or 410-502-9410 by April 19

Confirmed speakers:

  • Gerald Brandacher, M.D. Scientific Director, Composite Tissue Allotransplantation (Reconstructive Transplant) Program
  • Robert Brodsky, M.D. Director, Division of Hematology
  • Jeff Bulte, Ph.D. Director, Cellular Imaging Section, Institute for Cell Engineering (INBT affiliated faculty)
  • Mark Donowitz, M.D. Director, Center for Epithelial Disorders; Director, Conte GI Core Research Center
  • Gary Gerstenblith, M.D. Professor, Medicine
  • Warren Grayson, Ph.D. Assistant Professor, Biomedical Engineering (INBT affiliated faculty)
  • Jun Liu, Ph.D. Professor, Pharmacology and Molecular Sciences
  • Erika Matunis, Ph.D. Associate Professor, Cell Biology
  • Guo-li Ming, M.D., Ph.D. Professor, Neurology and member of the Institute for Cell Engineering (INBT affiliated faculty)
  • Ronald Schnaar, Ph.D. Professor, Pharmacology and Molecular Sciences; Director, Lung Inflammatory Disease Program of Excellence in Glycoscience

We look forward to seeing you on April 29!

Download the color flyer here.