Mesenchymal cell migrating through a three-dimensional (3-D) matrix typically involves major matrix remodeling. The direction of matrix deformation occurs locally in all 3 dimensions, which cannot be measured by current techniques. To probe the local, 3-D, real-time deformation of a collagen matrix during tumor cell migration, we have developed a new assay where matrix-embedded beads are tracked simultaneously in all 3 directions with high resolution.

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