Nanobio Tool Repository
Probing cell-virus interactions at single-molecule resolution
This technique measures the dynamic binding interactions between glycoproteins on a viral envelope and receptors on the surface of the cell. Analysis of the data allows us to map the tensile strengths, lifetimes, and energy barriers of individual intermolecular bonds between CCR5 tropic HIV-1 gp120 and its receptors CD4 and CCR5 or CXCR4 as a function of the interaction time.
