Funding Opportunities

Department of Defense Amyotrophic Lateral Sclerosis Research Program (PRE-APPLICATION REQUIRED)

due: 31-12-2115 Research DoD required
Therapeutic Development Award- More info on grants.gov expected April 2015
Pre-application is required; application submission is by invitation only.

Supports post-discovery, preclinical development of therapeutics for ALS

Types of efforts that will be supported include:

Development of pharmacological agents up to IND submission

Demonstration of target selectivity and mechanism of action, optimization of potency and pharmacology, studies of formulation, stability and production methods based on Good Manufacturing Practices.

Development of biomarkers to confirm action on specific molecular targets or biomarkers of clinical progress

Preliminary data relevant to the phase of preclinical development are required.

Clinical trials are not allowed under this mechanism

New for FY15: Does not support screening, or development of screens or models.
Budget Requirements
Maximum funding of $1,000,000 for direct costs (plus indirect costs)

New for FY15: Maximum period of performance is 2 years

The FY15 Defense Appropriations Act provides $7.5 million (M) to the Department of Defense Amyotrophic Lateral Sclerosis Research Program (ALSRP) to support innovative, high-impact Amyotrophic Lateral Sclerosis research. As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency, Research, Development, and Acquisition (DHA RDA) Directorate manages and executes the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation. The executing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP).

The ALSRP is providing the information in this pre-announcement to allow investigators time to plan and develop applications. FY15 ALSRP Program Announcements and General Application Instructions for the following award mechanisms are anticipated to be posted on the Grants.gov website in April 2015. Pre-application and application deadlines will be available when the Program Announcements are released. This pre-announcement should not be construed as an obligation by the government.