International nanobio research opportunity for Hopkins students

Belgium is well known for developing many fine things: chocolate…beer…waffles.

Nanobiotechnology also tops the country’s list of research and development activities. Undergraduate and graduate students at Johns Hopkins University now have the chance to apply for a short-term nanobio research program in Belgium hosted by the Johns Hopkins Institute for NanoBioTechnology (INBT).

Applications are now being accepted for INBT’s summer 2012 International Research Experience for Students (IRES) program. The application deadline is March 25, 2012. INBT funds several research internships at IMEC, The Inter-University MircroElectronics Centre, in Leuven, Belgium through the IRES program, funded by the National Science Foundation. Students work on collaborative research projects organized between Hopkins faculty and IMEC researchers at IMEC’s world-class microfabrication facility and learn to design, fabricate and test a wide range of biomedical devices. The internships are for 10 to 12 weeks and include travel expenses, accommodations and a stipend.

The IRES program is open to Johns Hopkins undergraduate and graduate students who are science or engineering majors and have at least one year of research experience. Graduate students should have additional relevant research experience. Students from under-represented racial/minority groups and women in science and engineering are especially encouraged to apply.

To apply for this unique opportunity, send your resume along with a summary of your research experience and the name and contact information of at least one faculty research advisor to Ashanti Edwards at aedwards@jhu.edu. Only U.S. citizens and permanent residents are eligible to apply. A very limited number of IRES positions are available, so don’t wait until the deadline to apply.

Nanobiotechnology in Belgium is great, but their waffles might be better. (Mike Keung 2009)

If you have additional questions, please contact Ashanti Edwards at aedwards@jhu.edu or (410) 516-6572 for more information on the application process.

Additional information:

Summer at IMEC Video Blog

Summer at IMEC 2011 Blog

Summer at IMEC 2009-2010 Blog

IMEC

INBT

Story by Mary Spiro

Postdoctoral Position in Flow Cytometry, Receptor Quantification for Cancer Angiogenesis

NBT affiliated researcher Dr. Aleksander Popel seeks an independent and motivated researcher for a Postdoctoral Fellowship in his Systems Biology laboratory in the Department of Biomedical Engineering, The Johns Hopkins School of Medicine.

The successful candidate will join a research team that combines molecular and imaging tools to discover and elucidate mechanisms of tumor angiogenesis and drug action.

Specific skills will include cell-surface receptor biology and imaging, flow cytometry (FACS) (see Imoukhuede PI, Popel AS. Quantification and cell-to-cell variation of vascular endothelial growth factor receptors. Exp Cell Res. 317:955-65, 2011). Experiences with Quantum Dots imaging and tissue dissociation are a plus. Knowledge of murine models of cancer is desirable.

Applicant must have a recent doctoral degree with a demonstrated record of innovative scientific accomplishments as evidenced by first-author papers published or accepted in a premiere journal.

Qualified candidates must also demonstrate outstanding communication skills, have a strong passion and commitment to science, and work well within a group.

This position is for US citizens, permanent residents or holders of an F1/OPT visa with at least six months of work authorization left.

Johns Hopkins University is an Equal Opportunity Employer with a commitment to diversity. All individuals are encouraged to apply.

How to apply: Email curriculum vitae and names of three references to: Dr. A.S. Popel, Dept. of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205. Telephone 410-955-6419, E-mail apopel@jhu.edu

Visit Dr. Popel’s website here.

Johns Hopkins and UVa co-host 2-day imaging workshop

Learn about state-of-the-art imaging methods at the In Vivo Preclinical Imaging: an Introductory Workshop, March 20-21 at Johns Hopkins University’s School of Medicine Turner Auditorium. Co-hosted by Johns Hopkins University, the University of Virginia and the Society of Nuclear Medicine (SNM), this workshop will bring together gifted lecturers to cover the fundamentals of in vivo small animal imaging.

The workshop will cover an incredible breadth of material of interest and value to physicians, scientists (including postdoctoral fellows and graduate students) and scientific laboratory professionals interested in using molecular imaging for in vivo biomedical applications. Individuals with experience in small animal imaging as well as beginners are welcome. Participants learn the fundamentals of various small animal imaging modalities. A limited number of participants will also have the opportunity to register to attend a half-day, hands on workshop held on the afternoon of the second day, March 21. Registration for this unique opportunity is on first-come first-served, so don’t wait to register.

Speakers will address imaging modalities including MRI and MRS, PET, SPECT, optical imaging (bioluminescence & fluorescence imaging/tomography), ultrasound, x-ray CT, photoacoustic imaging and multimodality imaging. Speakers will also examine instrumentation, acquisition and reconstruction, MR/SPECT/PET imaging probes, targets and applications, small animal handling, techniques for imaging infectious disease models and data analysis.

More information about the workshop, including a full agenda of topics, registration and details about transportation and lodging can be found at the workshop website. www.snm.org/pci2012.

INBT Happy Hour – Friday 4/13

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REU Deadline March 1, 2012

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Engineers put a new ‘twist’ on lab-on-a-chip

Close-up of a cylindrically-shaped microfluidic device with two fluorescent solutions flowing through. Reproduced with permission from Nature Communications.

A leaf works something like a miniature laboratory. While the pores on the leaf surface allow it to channel nutrients in and waste products away from a plant, part of a leaf’s function also lies in its ability to curl and twist. Engineers use polymers to create their own mini-labs, devices called “labs-on-a-chip,” which have numerous applications in science, engineering and medicine. The typical flat, lab on a chip, or microfluidic device, resembles an etched microscopy cover slip with channels and grooves.

But what if you could get that flat lab-on-a-chip to self-assemble into a curve, mimicking the curl, twist or spiral of a leaf? Mustapha Jamal, a PhD student and IGERT fellow from Johns Hopkins Institute for NanoBioTechnology, has created a way to make that so.

Jamal is the lead author on “Differentially photo-crosslinked polymers enable self-assembling microfluidics,” published November 8, 2011 in Nature Communications. Along with principle investigator David Gracias, associate professor of Chemical and Biomolecular Engineering in the Whiting School of Engineering, and fellow graduate student Aasiyeh Zarafshar, Jamal has developed, for the first time, a method for creating three-dimensional lab-on-a-chip devices that can curl and twist.

The process involves shining ultraviolet (UV) light on a film of a substance called SU-8. Film areas closer to the light source become more heavily crosslinked than layers beneath, which on solvent conditioning creates a stress gradient.

Immersing the film in water causes the film to curl. Immersion in organic solvents like acetone causes the film to flatten. The curling and flattening can be reversed. The result, Jamal said, is the “self-assembly of intricate 3D devices that contain microfluidic channels.” This simple method, he added, can “program 2D polymeric (SU-8) films such that they spontaneously and reversibly curve into intricate 3D geometries including cylinders, cubes and corrugated sheets.”

Members of the Gracias lab have previously created curving and folding polymeric films consisting of two different materials. This new method achieves a stress gradient along the thickness of a single substance. “This provides considerable flexibility in the type and extent of curvature that can be created by varying the intensity and direction of exposure to UV light,” Gracias said.

Gracias explained that the method works with current protocols and materials for fabricating flat microfluidic devices. For example, one can design a 2D film with one type of lab-on-a-chip network, and then use their method to shape it into another geometry, also with microfluidic properties.

Fluorescent image of curved, self-assembled microfluidic device. Reproduced with permission from Nature Communications.

“Since our approach is compatible with planar lithography methods, we can also incorporate optical elements such as split ring resonators that have unique optical features. Alternatively, flexible electronic circuits could be incorporated and channels could be used to transport cooling fluids” Gracias said.

Tissue engineering is among the many important applications for 3D microfluidic devices, Gracias said. “Since many hydrogels can be photopolymerized, we can use the methodology of differential cross-linking to create stress gradients in these materials,” Gracias explained. “We plan to create biodegradable, vascularized tissue scaffolds using this approach.”

Link to the journal article here.

Story by Mary Spiro

 

 

Hopkins faculty to present at American Society for NanoMedicine meeting

© Liudmila Gridina | Dreamstime.com

The American Society for NanoMedicine (ASNM) will hold its third annual meeting November 9 -11 at the Universities at Shady Grove Conference Center in Gaithersburg, Md. This year ASNM has worked closely with the Cancer Imaging Program, National Cancer Institute, and National Institutes of Health to create a conference with a special focus on nano-enabeled cancer diagnostics and therapies, and the synergy of the combination of nano-improved imaging modalities and targeted delivery.

The program also focuses on updates on the newest Food and Drug Administration, nanotoxicity, nanoparticle characterization, nanoinformatics, nano-ontology, results of the latest translational research and clinical trials in nanomedicine, and funding initiatives. This year’s keynote speaker is Roger Tsien, 2008 Nobel Prize Laureate. Numerous other speakers and breakout sessions are planned for the three day event. Two speakers affiliated with Johns Hopkins include Justin Hanes and Dmitri Artemov. Hanes is a professor of nanomedicine in the department of ophthalmology at the Johns Hopkins School of Medicine. Artemov is an associate professor of radiology/magnetic resonance imaging research, also at the School of Medicine.

The deadline for the poster abstracts is October 1. The top four posters submitted by young (pre and post doctoral) investigators will be selected to give a short 10-minute (eight slides) oral presentation on November 11.

ASNM describes itself as a “a non-profit, open, democratic and transparent professional society…focus(ing) on cutting-edge research in nanomedicine and moving towards realizing the potential of nanomedicine for diagnosis, treatment, and prevention of disease.” More information about the ASNM can be found on the Society’s official website.

 

 

Collagen video scores high in magazines reader’s choice vote

Screen capture from INBT’s video on collagen mimetic peptides.

The Scientist magazine has announced its annual Multimedia Awards—the Labbys—and Johns Hopkins Institute for NanoBioTechnology’s video on collagen mimetic peptides has been selected as a finalist. According to the voting, we are a strong second in the race. It appears voting is continuing well past the original June 30 deadline. So keep voting!

Help choose us as the top science video by going to this website (http://the-scientist.com/2011/06/15/2011-labby-video-finalists/#vote)  and selecting “Mimicking Collagen.” The video features Michael Yu, associate professor of materials science and engineering and some fantastic animations and illustration from INBT’s Animation studio. Animations in the video were created by Ella McCrea, a graduate from the Maryland Institute College of Art, and Nathan Weiss, a masters graduate from Johns Hopkins University.

Winners of the reader’s choice will be announced in the magazine and online in September. Top picks will also be chosen by The Scientist’s panel of judges, which includes the father of the infographic Nigel Holmes, Kirsten Sanford of the Science Channel (aka Dr. KiKi), Jeffrey Segall of the Albert Einstein College of Medicine in New York City, and David Kirby of the University of Manchester.

You can only vote once, so share this link with your friends.

 

 

Come to the NanoBio Film Festival 11 a.m., 6/29 in Krieger 205

Charli Dvoracek storyboarding a video. Photo by Mary Spiro

Johns Hopkins Institute for NanoBioTechnology (INBT) hosts the NanoBio Film Festival on June 29, 11 a.m. in Krieger 205. See the world premiere of three short videos made by members of INBT’s course on science communications. Free for Hopkins community.

Videos featured in this film festival describe the current research of students working in INBT affiliated laboratories. Students in the course learn how to communicate their work in nontechnical terms for general audiences. They work in teams to write, direct, film and produce the videos within a two-week time frame. The producers will be on hand to describe their experience making the videos and to answer questions.

The INBT film festival is part of the institute’s free professional development seminar series. Topics are geared toward undergraduate and graduate students.

Future seminars include:

  • July 13: Adam Steel, PhD, Director of Systems Engineering at Becton Dickinson, will discuss medical device development. Dr. Steel joined BD in 2005. Previously he was vice president of research and development at MetriGenix. He earned his PhD in analytical chemistry at the University of Maryland College Park and undergraduate degrees in chemistry and mathematics from Gettysburg College. He completed a postdoctoral fellowship in medical device development at the National Institutes of Standards and Technology.
  • July 27: Grant submission process and how to obtain funding; a roundtable discussion with INBT affiliated postdoctoral students.

For additional information on INBT’s professional development seminar series, contact Ashanti Edwards, INBT’s Academic Program Administrator at Ashanti@jhu.edu.

 

 

Voting for Johns Hopkins video in multimedia contest ends June 30

The Scientist magazine has announced its annual Multimedia Awards—the Labbies—and Johns Hopkins Institute for NanoBioTechnology’s video on collagen mimetic peptides has been selected as a finalist. But that just means we are in the finals. We need your vote to win!

Help choose us as the top science video by going to this website (http://ht.ly/5mZ9D) and voting for “Mimicking Collagen.” The video features Michael Yu, associate professor of materials science and engineering and some fantastic animations and illustration from INBT’s Animation studio.

Voting ends June 30, 2011 and winners of the reader’s choice will be announced in the magazine and online in September. Top picks will also be chosen by The Scientist’s panel of judges, which includes the father of the infographic Nigel Holmes, Kirsten Sanford of the Science Channel (aka Dr. KiKi), Jeffrey Segall of the Albert Einstein College of Medicine in New York City, and David Kirby of the University of Manchester.

So vote now and often! Share this link with your friends.

Watch the video that made the Labby finals.

Collagen Mimetic Peptides