DEADLINE EXTENDED: Applications accepted for INBT IRES until Feb 14

If you have been curious to discover what laboratory work is like in another country, now is your chance to apply for one of INBT’s coveted positions as an international undergraduate researcher. Applications are now being accepted for our National Science Foundation funded International Research Experience for Undergraduates in Leuven, Belgium with IMEC.  The deadline for applications is February 14, 2014. The opportunities are for Johns Hopkins University students.

IMEC clean roomIMEC boasts world-class micro- and nano-fabrication facilities and a campus with more than 1,000 researchers from around the globe who are collaborating on leading-edge projects. Belgium boasts waffles, beer and chocolate. Really, you can’t go wrong here.

INBT international research internships focus on a project of mutual interest to Johns Hopkins faculty and to IMEC investigators. INBT has a long-standing research collaboration agreement with IMEC, one of the world’s leading research organizations focusing on silicon nanotechnology headquartered in Leuven, Belgium. Since 2009, students, both undergraduates and postgraduates, from INBT labs have had the opportunity to participate in internships at IMEC’s state-of-the-art research facility. These internships have the dual purpose of providing international research experience for students as well as furthering the research interests of both Hopkins and IMEC.

To read about some of the previous experiences of our IRES participates, visit INBT’s Summer at IMEC blog here.

To apply, send the following items to Tom Fekete, INBT’s director of corporate partnerships, before Feb. 1: tfekete1@jhu.edu.

  • CV/Resume
  • Research Statement
  • Letter of Recommendation

If you are not sure what you would like to work on, Tom has a list of possible research areas that you can inquire about as well. If you have any questions, please feel free to contact Tom.  If he is unavailable, please contact Ashanti Edwards, INBT’s Academic Program Administrator at ashanti@jhu.edu.

Student engineers solve village problems through Global Engineering Innovation Program

Johns Hopkins Institute for NanoBioTechnology hosts teams of students to travel to foreign countries to apply their engineering skills to solve local problems through a program called Global Engineering Innovation. This story, featured in the Johns Hopkins Gazette, describes one of those projects in Nazaçu, along the Amazon River in Brazil: the design and production of a safer cassava mill that reduces the risk of injury. INBT has also hosted teams in Tanzania and India.

GEU design team with the finalized pedal power grain mill in Tanzania (from left to right) Kristen Kosielski, Jeannine Coburn, Iwen Wu and local resident Jackson. (Photo courtesy Jeannine Coburn)

GEU design team with the finalized pedal power grain mill in Tanzania (from left to right) Kristen Kosielski, Jeannine Coburn, Iwen Wu and local resident Jackson. (Photo courtesy Jeannine Coburn)

Said program director Jennifer Elisseeff, the Jules Stein Professor of Ophthalmology at the Wilmer Eye Institute: “This program has enormous potential to have students visit various communities around the world to design and solve real problems that can help people in their daily lives.”

Read more from the Gazette article here.

Read more about the INBT GEI program here.

 

Science writers’ bootcamp focuses on neuroscience

The sixth annual Johns Hopkins Science Writers’ Boot Camp will feature Johns Hopkins experts in neuroscience and medicine discussing the latest in mapping the brain, learning and memory, recovery after brain injury and more.

WHEN: Monday, April 28, 2014, 9 a.m. to 4:30 p.m. with reception following

WHERE: The National Press Club, 529 14th St. NW, Washington, DC 20045

For more information please visit this link. 

swbc14Confirmed speakers:

  • Marilyn Albert, Ph.D., Director of the Division of Cognitive Neuroscience in the Department of Neurology
  • Amy Bastian, Ph.D., Professor of Neuroscience and member of Kennedy Krieger Institute
  • Henry Brem, M.D., Harvey Cushing Professor and Chairman of the Department of Neurosurgery
  • Aravinda Chakravarti, Ph.D., Professor of Medicine
  • David Foster, Ph.D., Assistant Professor of Neuroscience
  • Argye Hillis, M.D., M.A., Executive Vice Chair of the Department of Neurology and Co-Director of the Cerebrovascular Division
  • Richard Huganir, Ph.D., Director of the Solomon H. Snyder Department of Neuroscience and Co-director of the Brain Science Institute
  • John Krakauer, M.D., Director of the Center for the Study of Motor Learning and Brain Repair
  • David Linden, Ph.D., Professor of Neuroscience
  • Mollie Meffert, M.D., Ph.D., Associate professor of Biological Chemistry
  • Jeffrey Rothstein, M.D., Ph.D., Director of the Robert Packard Center for ALS Research and Director of the Brain Science Institute
  • Hongjun Song, Ph.D., Director of the Stem Cell Program at the Institute for Cell Engineering

 

Interning in INBT’s animation studio

Students from the Maryland Institute College of Art, aka MICA, have been interning at the Johns Hopkins Institute for NanobioTechnology’s Animation Studios pretty much since the studio came into existence in 2007. Studio director and INBT web guru Martin Rietveld organizes the student internships each semester and every summer.

Anny Lai.

Anny Lai.

Most evenings, MICA graphic design major Anny Lai can be found in the INBT animation computer lab working on animating the process of stem cell based tissue regeneration. She has blogged about her experience here.

For more information about internships with INBT, which are open to JHU students, MICA students and others training in the arts, go to this link. Programs used in the animation studio include Cinema 4D, AfterEffects and Adobe Flash.

Even students without training or a background in the arts are welcome to take Martin’s independent study course in animation. Students in engineering and the basic sciences have created smaller animation projects that they use in academic presentations or have submitted to peer-reviewed journals for publication.

Contact Martin at rietveld@jhu.edu for more information.

What is INBT?

At Johns Hopkins University, the Institute for NanoBioTechnology is sort of a strange hybrid animal— a unique entity in academia. Founded in 2006, we are a virtual center that draws faculty membership from four divisions – the medical school, engineering school, school of arts and sciences and from public health.

Four different divisions comprise INBT.

Four different divisions comprise INBT.

Two faculty members, Peter Searson, the Joseph R. and Lynn C. Reynolds Professor in the Department of Materials Science and Engineering, and Denis Wirtz, the Theophilus H. Smoot Professor in the Department of Chemical and Biomolecular Engineering, started INBT. They thought it made sense to combine the efforts of people in engineering with people working in the medical and basic sciences as well as in public health to better solve problems in health care. We have more than 220 affiliated faculty members. There are no other centers or institutes at Hopkins with as many participants from as many different disciplines.

Any faculty member can become a member of INBT; they just have to have an interest in incorporating nanobiotechnology—or science at the scale of just a few atoms—into their research. Researchers at INBT are working on everything from drug delivery systems to solving problems in basic science and engineering using nanobiotechnology.

Physically, INBT is located on the Johns Hopkins Homewood campus in Suite 100 of Croft Hall. That’s where our administrative offices are and some of our faculty members have laboratories in this building. But our research occurs wherever our faculty members are working, and much of that is at the School of Medicine. In fact, nearly half of our members come from the medical school. Faculty members in other divisions are mostly likely collaborating with people at the School of Medicine.

At INBT, we search for funding opportunities for our members and offer small seed grants that help collaborators launch projects. Sometimes these projects are later funded and sustained by larger federal grants. We feel good about helping new ideas find “legs”.

In addition, we train up-and-coming scientists and engineers from high school through the postdoctoral level in our affiliated labs. These include short-term summer programs as well as highly competitive government funded research experiences and fellowships that last several years. INBT is educating the next generation of researchers who will solve problems at the interface of science, engineering and medicine. Our graduate students who fulfill specific requirements are awarded a Certificate of Advanced Study in NanoBioTechnology.

We have global outreach programs as well. INBT has funded research teams to India and Tanzania to solve engineering problems in local communities. Sometimes the challenges are medical, and sometimes they are purely engineering, but the teams much use local materials and resources to accomplish their goals.

Finally, we have industry affiliations. By working with companies in the U.S. and worldwide, we are developing training opportunities for our students that result in the development of new knowledge and hopefully new patented and marketable products. We don’t want to keep our innovations in the lab; we want to bring them to people for the benefit of humankind.

So in a nutshell, that’s what INBT is all about. To learn more about some of our specific programs and about some of the other centers we have launched under the INBT “brand”, read the other articles in this series. You can also watch this video about INBT. 

This article is part of a series of brief reports on INBT and its different components and programs. Together, we hope these articles will help readers inside and outside of the Johns Hopkins University community to understand what INBT is and what we do.

 

My life as an undergraduate researcher

I joined the Denis Wirtz Lab in the Institute for NanoBioTechnology the summer after my freshman year. I was nervous to start in a lab with such brilliant scientists, but everyone was really welcoming and friendly. After observing graduate students and postdoctoral fellows in the lab, I was given my own project. I had free rein to design the protocol and figure out how to analyze the data.

Katherine Tschudi. (Photo by Mary Spiro)

Katherine Tschudi. (Photo by Mary Spiro)

At first, it was difficult, but working through this and the inevitable obstacles that came made me a better researcher and scientist. I am incredibly grateful for this experience as a senior as I look back and see how the Wirtz Lab has helped me grow professionally and academically.

As a Chemical and Biomolecular Engineering major at Hopkins, we study how different physical, chemical, and biological processes work. In Wirtz Lab, I have had the opportunity to see this in action. Through my two years, I’ve looked at the differences in cell proliferation and motility for metastatic and primary cancer cells. I learned how to ask the right questions, how to think critically about data, and how to solve problems. Using the skills from Wirtz Lab, I also had the amazing opportunity to research abroad in Switzerland at the École Polytechnique Fédérale de Lausanne.

In February 2014, I will be starting a job at Genentech, and I give a lot of credit to the great undergraduate research experience I’ve had in INBT. If you want to read more about my research experiences, I wrote a blog for Hopkins Admissions during my years at Hopkins and have around six posts detailing my experience.

Click here to read Kate’s six blog entires about working in the Wirtz Lab at Hopkins-Interactive.

Kate Tschudi earned her degree in Chemical and Biomolecular Engineering in December 2013. She is just one of the many undergraduate students who have benefitted by participating in undergraduate research in an INBT affiliated laboratory. Johns Hopkins University, founded as a research institute, emphasizes undergraduate research experiences, and more than half of the undergraduates participate in research projects at some point during their academic careers here.  Johns Hopkins Institute for NanoBioTechnology actively supports undergraduate research opportunities and in an informal way helps match students to projects in laboratories of affiliated faculty members. 

Related Links:

Wirtz Lab

 

Studying cells in 3D, the way it should be

When scientists experiment on cells in a flat Petri dish, it’s more been a matter of convenience than anything that recapitulates what that cell experiences in real life. Johns Hopkins professor Denis Wirtz for some time has been growing and studying cells three dimensions, rather than the traditional two dimensions. And pretty much, he’s discovered that a lot of what we think we know about cells is dead wrong.

cancer-in-3d-impact_0

Cell in 3D. Image by Anjil Giri/Wirtz Lab

In this recent article by Johns Hopkins writer Dale Keiger, you will discover what Wirtz has discovered through his investigations. Furthermore, you will find out about the man behind these revolutionary ideas that are turning basic cell biology upside-down, as well as challenge a lot of what we thought we understood about diseases like cancer.

Wirtz directs the Johns Hopkins Physical-Sciences Oncology Center and is associate director and co-founder of Johns Hopkins Institute for NanoBioTechnology. He recently launched the Center for Digital Pathology. He is a the Theophilus Halley Smoot professor of chemical and biomolecular engineering.

You can read the entire magazine article “Moving cancer research out of the Petri dish and into the third dimension” online here at the JHU Hub.

‘Fast Forward’ talk today on tech transfer with Jim Stefansic

FastForward

The 2013 FastForward Entrepreneurship Speaker Series launches Thursday, Dec. 12 at 4 p.m.  with a lecture by Jim Stefansic, a 1994 Johns Hopkins University alumnus from the Department of Biomedical Engineering.

What: “Founding Pathfinder Therapeutics: From Technology Transfer to Venture Capital to Market”

When: 4 p.m., on Thursday, Dec. 12. Free parking and shuttles leaving every 10 minutes from Mason Hall

Where: Stieff Silver Building

Stefansic served as co-founder and CEO of Pathfinder Therapeutics, Inc., a Nashville-based medical device company. He was instrumental in raising more than $17 million in venture capital and SBIR funding as well as bringing Pathfinder’s product to market.

Today Stefansic serves as director of commercialization at Launch Tennessee, a public-private partnership focused on the development of regional high-growth companies. Stefansic received his BS degree in Biomedical Engineering from Johns Hopkins University, his PhD in Biomedical Engineering from Vanderbilt University, and his MBA from Belmont University, where he is an adjunct professor of business.

Picture this: Transcription ‘twists’ toward metastasis

Mol Cancer Res Cover (1)

Molecular Cancer Research Cover

Researchers associated with Johns Hopkins Physical Sciences-Oncology Center, Johns Hopkins School of Medicine and School of Public Health have published “The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis,” in a recent issue of the journal Molecular Cancer Research. An illustration related to the work graced the cover.

Authors on the paper include co-lead authors Rajendra P. Gajula and Sivarajan T. Chettiar,  as well as Russell D. Williams, Saravanan Thiyagarajan, Yoshinori Kato, Khaled Aziz, Ruoqi Wang, Nishant Gandhi, Aaron T. Wild, Farhad Vesuna, Jinfang Ma, Tarek Salih, Jessica Cades, Elana Fertig, Shyam Biswal, Timothy F. Burns, Christine H. Chung, Charles M. Rudin, Joseph M. Herman, Russell K. Hales, Venu Raman, Steven S. An and corresponding author Phuoc T. Tran

Here is an abstract of their paper and caption for the cover:

“Twist1 plays key roles during development and is a master transcriptional regulator of the epithelial-mesenchymal transition that promotes cancer metastasis. We demonstrated three important findings in prostate cancer cells that overexpress Twist1: (1) Twist1 leads to elevated cytoskeletal stiffness and traction forces at the migratory edge of cell collections; (2) The Twist box domain is required for Twist1-induced pro-metastatic in vitro properties and in vivo metastases; and (3) Hoxa9 is a novel Twist1 transcriptional target that is required for Twist1-induced pro-metastatic phenotypes. Targeting the Twist box domain and Hoxa9 may effectively limit prostate cancer metastatic potential.”

Visit the journal here: Molecular Cancer Research 

 

Veltri presents PS-OC hosted talk on digital pathology and prostate cancer

Robert Veltri, associate professor Of Urology and Oncology at the Johns Hopkins School of Medicine and Director of the Fisher Biomarker Biorepository Laboratory, will  present the talk Quantitative Histomorphometry of Digital Pathology: Case study in prostate cancer,” to members of the Denis Wirtz Lab and the Johns Hopkins Physical Sciences-Oncology Center on Monday, December 9 at 2 p.m. in Croft G40 on the Homewood campus. Seating is limited.

veltri

Robert Veltri

Veltri studies the biomarkers for prostate and bladder cancer and is collaborating on applications of Quantitative Digital Image Analysis (QDIA) using microscopy to quantify nuclear structure and tissue architecture. Collaborations include Case Western Reserve University biomedical engineering and the University of Pittsburgh Electrical Engineering departments studying to assess cancer aggressiveness in prostate cancer (PCa). Furthermore,  he is studying the application of molecular biomarkers for prostate (CaP) and bladder cancer (BlCa) detection and prognosis. Veltri’s work is funded by the National Cancer Institute’s PS-OC program grant), Early Detection Research Network (EDRN), and the Department of Defense related to research on Active Surveillance for PCa. He is also a co-investigator on a SBIR-I and II grant studying the application of microtransponders to multiplex molecular urine and serum biomarker testing for CaP.  Veltri has authored over 152 scientific publications and is either inventor or co-inventor on over twenty patents and two trademarks.