Hopkins Biomaterials Day Symposium Oct. 29

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Johns Hopkins Institute for NanoBioTechnology is a sponsor of the annual Biomaterials Day Symposium to be held Friday, Oct. 29 , from 8 a.m. to 5 p.m. in Charles Commons at the Homewood campus.

The goal of this of regional mini-symposium is to show-case all biomaterials related research happening at Johns Hopkins University, University of Maryland, and Pennsylvania State University, to stimulate further collaborations among peers, and to promote student participation in biomaterials research at all levels. Several keynote speakers will be giving talks on various aspects of biomaterials science, engineering and applications.

Join INBT, JHU and our neighboring research universities for this day-long event. You and your lab are invited to share your work on biomaterials at this symposium. Previously presented research may be presented here again. The registration is free and lunch is included.

Society for Biomaterials

Cells studied in 3-D may reveal novel cancer targets

Stephanie Fraley

Stephanie Fraley, a doctoral student in chemical and biomolecular engineering, was lead author of the study. Photo by Will Kirk/HomewoodPhoto.jhu.edu

Showing movies in 3-D has produced a box-office bonanza in recent months. Could viewing cell behavior in three dimensions lead to important advances in cancer research? A new study led by Johns Hopkins University engineers indicates it may happen. Looking at cells in 3-D, the team members concluded, yields more accurate information that could help develop drugs to prevent cancer’s spread.

“Finding out how cells move and stick to surfaces is critical to our understanding of cancer and other diseases. But most of what we know about these behaviors has been learned in the 2-D environment of Petri dishes,” said Denis Wirtz, director of the Johns Hopkins Engineering in Oncology Center and principal investigator of the study. “Our study demonstrates for the first time that the way cells move inside a three-dimensional environment, such as the human body, is fundamentally different from the behavior we’ve seen in conventional flat lab dishes. It’s both qualitatively and quantitatively different.”

One implication of this discovery is that the results produced by a common high-speed method of screening drugs to prevent cell migration on flat substrates are, at best, misleading, said Wirtz, who also is the Theophilus H. Smoot Professor of Chemical and Biomolecular Engineering at Johns Hopkins. This is important because cell movement is related to the spread of cancer, Wirtz said. “Our study identified possible targets to dramatically slow down cell invasion in a three-dimensional matrix.”

When cells are grown in two dimensions, Wirtz said, certain proteins help to form long-lived attachments called focal adhesions on surfaces. Under these 2-D conditions, these adhesions can last several seconds to several minutes. The cell also develops a broad, fan-shaped protrusion called a lamella along its leading edges, which helps move it forward. “In 3-D, the shape is completely different,” Wirtz said. “It is more spindlelike with two pointed protrusions at opposite ends. Focal adhesions, if they exist at all, are so tiny and so short-lived they cannot be resolved with microscopy.”

The study’s lead author, Stephanie Fraley, a Johns Hopkins doctoral student in Chemical and Biomolecular Engineering, said that the shape and mode of movement for cells in 2-D are merely an “artifact of their environment,” which could produce misleading results when testing the effect of different drugs. “It is much more difficult to do 3-D cell culture than it is to do 2-D cell culture,” Fraley said. “Typically, any kind of drug study that you do is conducted in 2D cell cultures before it is carried over into animal models. Sometimes, drug study results don’t resemble the outcomes of clinical studies. This may be one of the keys to understanding why things don’t always match up.”

collagen fibers

Reflection confocal micrograph of collagen fibers of a 3D matrix with cancer cells embedded. Image by Stephanie Fraley/Wirtz Lab

Fraley’s faculty supervisor, Wirtz, suggested that part of the reason for the disconnect could be that even in studies that are called 3-D, the top of the cells are still located above the matrix. “Most of the work has been for cells only partially embedded in a matrix, which we call 2.5-D,” he said. “Our paper shows the fundamental difference between 3-D and 2.5-D: Focal adhesions disappear, and the role of focal adhesion proteins in regulating cell motility becomes different.”

Wirtz added that “because loss of adhesion and enhanced cell movement are hallmarks of cancer,” his team’s findings should radically alter the way cells are cultured for drug studies. For example, the team found that in a 3-D environment, cells possessing the protein zyxin would move in a random way, exploring their local environment. But when the gene for zyxin was disabled, the cells traveled in a rapid and persistent, almost one-dimensional pathway far from their place of origin.

Fraley said such cells might even travel back down the same pathways they had already explored. “It turns out that zyxin is misregulated in many cancers,” Fraley said. Therefore, she added, an understanding of the function of proteins like zyxin in a 3-D cell culture is critical to understanding how cancer spreads, or metastasizes. “Of course tumor growth is important, but what kills most cancer patients is metastasis,” she said.

To study cells in 3-D, the team coated a glass slide with layers of collagen-enriched gel several millimeters thick. Collagen, the most abundant protein in the body, forms a network in the gel of cross-linked fibers similar to the natural extracellular matrix scaffold upon which cells grow in the body. The researchers then mixed cells into the gel before it set. Next, they used an inverted confocal microscope to view from below the cells traveling within the gel matrix. The displacement of tiny beads embedded in the gel was used to show movement of the collagen fibers as the cells extended protrusions in both directions and then pulled inward before releasing one fiber and propelling themselves forward.

Fraley compared the movement of the cells to a person trying to maneuver through an obstacle course crisscrossed with bungee cords. “Cells move by extending one protrusion forward and another backward, contracting inward, and then releasing one of the contacts before releasing the other,” she said. Ultimately, the cell moves in the direction of the contact released last.

When a cell moves along on a 2-D surface, the underside of the cell is in constant contact with a surface, where it can form many large and long-lasting focal adhesions. Cells moving in 3-D environments, however, only make brief contacts with the network of collagen fibers surrounding them–contacts too small to see and too short-lived to even measure, the researchers observed.

“We think the same focal adhesion proteins identified in 2-D situations play a role in 3-D motility, but their role in 3-D is completely different and unknown,” Wirtz said. “There is more we need to discover.”

Fraley said her future research will be focused specifically on the role of mechanosensory proteins like zyxin on motility, as well as how factors such as gel matrix pore size and stiffness affect cell migration in 3-D.

Co-investigators on this research from Washington University in St. Louis were Gregory D. Longmore, a professor of medicine, and his postdoctoral fellow Yunfeng Feng, both of whom are affiliated with the university’s BRIGHT Institute. Longmore and Wirtz lead one of three core projects that are the focus of the Johns Hopkins Engineering in Oncology Center, a National Cancer Institute-funded Physical Sciences in Oncology Center. Additional Johns Hopkins authors, all from the Department of Chemical and Biomolecular Engineering, were Alfredo Celedon, a recent doctoral recipient; Ranjini Krishnamurthy, a recent bachelor’s degree recipient; and Dong-Hwee Kim, a current doctoral student.

Funding for the research was provided by the National Cancer Institute.  This study, a collaboration with researchers at Washington University in St. Louis, appeared in the June issue of Nature Cell Biology.

Related links:

Johns Hopkins Engineering in Oncology Center

Department of Chemical and Biomolecular Engineering

Watch a related video on YouTube

Story by Mary Spiro

INBT summer scholars “Extreme Makeover: Home Edition” Airs Sept. 26


From left, Matthew Green-Hill, Dwayne Thomas II, Donte Jones, Durrell Igwe. (Photo by Mary Spiro/INBT)

Swirling test tubes and swinging hammers set the stage for four talented Baltimore city high school students whose summer included working in Johns Hopkins University medical research laboratories and helping build a new home for some of their fellow scholars. The young men, all part of Baltimore’s Boys Hope/Girls Hope program, were supported equally by Johns Hopkins Institute for NanoBioTechnology (INBT) and the School of Medicine to gain experience conducting research. But the producers of ABC’s “Extreme Makeover: Home Edition” television show also put the boys (and a bunch of other folks) to work to construct a spacious home for the young women of Girls Hope. (The episode featuring the Boys Hope Girls Hope home build airs this Sunday, Sept 26 at 7 p.m. as the show’s 2-hour season premier. See video in links below.)

According to the organization’s website, Boys Hope/Girls Hope is a “privately funded, non-profit multi-denominational organization that provides at-risk children with a stable home, positive parenting, high quality education, and the support needed to reach their full potential.” In the summer of 2009, INBT hosted two students to work in labs at the Johns Hopkins School of Medicine. This summer INBT hosted four Boys Hope Girls Hope scholars.

Matthew Green-Hill, 18, a junior at Archbishop Curley High School and Donte Jones, 17, a sophomore at Archbishop Curley High School returned this summer and were joined by Dwayne Thomas, 16, a junior at Loyola Blakefield and Durrell Igwe, 16, a sophomore at Archbishop Curley. (Other students participate in Boys Hope Girls Hope, but only four scholars had summer jobs at Johns Hopkins.)


Dwayne Thomas II shows off his summer research efforts. (Photo by Christie Johnson/INBT)

Doug Robinson, associate professor of cell biology at the School of Medicine spear-headed the effort to bring Boys Hope Girls Hope scholars to Johns Hopkins through INBT. Each scholar was paired with a graduate student or postdoctoral fellow in their host labs to ensure that they were actively engaged in an aspect of a research. “The goal of this program was to provide our scholars with a summer experience that was challenging, enriching, and personally rewarding,” Robinson said. “Additionally, the students participated in a class three mornings a week where they worked on writing, reading, and mathematics skills.”

The summer experience concluded with a poster session where the scholars showed off what they had done with family, friends, other faculty members and staff. For example, Dwayne Thomas II worked with postdoctoral fellow Alexandra Surcel in Cell Biology in Robinson’s lab to conduct research on cytokinesis in the organism Dictyostelium.

“My summer experience was very important to me on so many levels,” Thomas said. “The quality education I received this summer was outstanding because I learned so much it will help next year in school. I feel like this has really prepared me for college in the near future and also for my dream of becoming a medical doctor. During the summer program, it taught me a lot about professionalism such the importance of arriving at work on time. I know that this experience has made me strive even harder because not many people receive the same type of opportunities I do.”

Donte Jones worked on the problem of malaria in the laboratory of Caren Meyers, assistant professor in the Department of Pharmacology and Molecular Sciences at the School of Medicine. Durrell Igwe spent his summer in the neuroscience laboratory of Howard Hughes Medical Institute investigator Alex Kolodkin in the department of neuroscience. Matthew Green-Hill participated in neurodegenerative disease research in the laboratory of Craig Montell, professor of biological chemistry at the School of Medicine.

A half dozen young women also study through Girls Hope, but unlike their male counterparts, the girls had no home where they could live with their adult mentors, only a parcel of land in the Hamilton section of Baltimore. Boys Hope/Girls Hope is completely voluntary and the organization does not serve as a legal guardian to the students, but participants have the option of living in the group house or at home with their own families. Many choose to live with their classmates in the group house.

The Boys Hope scholars wanted to help the Girls Hope scholars get their home built as soon as possible. So the boys sent a video requesting that the makers of the television Extreme Makeover: Home Edition to construct a house for the girls before the start of the next school year. The plea worked and before long, several city blocks along Fleetwood Ave. were cordoned off and filled with construction equipment and workers. The 11,000 square ft. home was built in nine short days, suffering a brief setback due to severe rainstorms. Look for more photos of the Girls Hope Home on the INBT website after the television reveal.

Related Links

Boys Hope/Girls Hope Baltimore

ABC TV Extreme Makeover: Home Edition

Girls Hope of Baltimore Gets an Amazing Gift from Extreme Makeover

Story by Mary Spiro

INBT launches Johns Hopkins Center of Cancer Nanotechnology Excellence

Martin Pomper and Peter Searson will co-direct INBT’s new Center of Cancer Nanotechnology Excellence (Photo: Will Kirk/Homewood-JHU)

Faculty members associated with the Johns Hopkins Institute for NanoBioTechnology have received a $13.6 million five-year grant from the National Cancer Institute to establish a Center of Cancer Nanotechnology Excellence. The new Johns Hopkins center brings together a multidisciplinary team of scientists, engineers and physicians to develop nanotechnology-based diagnostic platforms and therapeutic strategies for comprehensive cancer care. Seventeen faculty members will be involved initially, with pilot projects adding more participants later.

The Johns Hopkins Center of Cancer Nanotechnology Excellence, which is part of the university’s Institute for NanoBioTechnology, is one of several NCI-supported centers launched through a funding opportunity started in 2005. According to the NCI, the program was established to create “multi-institutional hubs that integrate nanotechnology across the cancer research continuum to provide new solutions for the diagnosis and treatment of cancer.”

Peter Searson, who is the Joseph R. and Lynn C. Reynolds Professor of Materials Science and Engineering in the Whiting School of Engineering and director of the Institute for NanoBioTechnology, will serve as the center’s director. The co-director will be Martin Pomper, professor of radiology and oncology at the School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

“A unique feature of the center is the integration of research, education, training and outreach, and technology commercialization,” Searson said.

To move these new technologies toward use by physicians, a Cancer Nanomedicine Commercialization Working Group will be established and headed by John Fini, director of intellectual property for the university’s Homewood campus. This group will be responsible for managing and coordinating the translational process.

Another special feature of the center will be its Validation Core, led by Pomper, who is also associate director of the Johns Hopkins In Vivo Cellular and Molecular Imaging Center and director of the Johns Hopkins Small Animal Imaging Resource Program.

“Validation is about assuring that the experimental products and results we generate are on target and able to measure the biological effects for which they’re intended,” he said.

Searson and Pomper said the center will consist of four primary research projects.

One project will seek methods to screen bodily fluids such as blood or urine for indicators of cancer found outside of the genetic code, indicators called epigenetic markers. Led by Tza-Huei “Jeff” Wang, associate professor of mechanical engineering in the Whiting School of Engineering; Stephen Baylin, the Virginia and Daniel K. Ludwig Professor of Cancer Research in the School of Medicine; and James Herman, a professor of cancer biology in the School of Medicine, this project will use semiconductor nanocrystals, also known as quantum dots, and silica superparamagnetic particles to detect DNA methylation. Methylation adds a chemical group to the exterior of the DNA and is a biomarker frequently associated with cancer.

A second project, led by Anirban Maitra, associate professor of pathology and oncology at the School of Medicine and the Johns Hopkins Kimmel Cancer Center, will focus on curcumin, a substance found in the traditional Indian spice turmeric. In preclinical studies, curcumin has demonstrated anti-cancer properties but, because of its physical size, it is not readily taken up into the bloodstream or into tissues. Engineered curcumin nanoparticles, however, can more easily reach tumors arising in abdominal organs such as the pancreas, Maitra said. This team will try to determine whether nanocurcumin, combined with chemotherapeutic agents, could become a treatment for highly lethal cancers, such as pancreatic cancer.

Hyam Levitsky, professor of oncology at the Johns Hopkins Kimmel Cancer Center, will lead a third project, which will seek to use a noninvasive method to monitor the effectiveness of vaccines for cancer and infectious diseases.

A final project will build on the work of Justin Hanes and Craig Peacock, professors in the School of Medicine, to deliver therapies directly to small cell lung cancer tissue via mucus-penetrating nanoparticles.

All research efforts will be supported by a nanoparticle engineering core, led by Searson, which will make and characterize a variety of nanomaterials. Another core, centering on bioinformatics and data sharing, will be led by Rafael Irizarry, professor of biostatistics at the Johns Hopkins Bloomberg School of Public Health.

Johns Hopkins Institute for NanoBioTechnology

Sidney Kimmel Comprehensive Cancer Center

Johns Hopkins Researchers Appointed to Governor’s Task Force to Study Nanobiotechnology

Peter Searson

Steve Desiderio

Maryland Gov. Martin O’Malley has appointed Peter Searson and Steve Desiderio, two researchers from The Johns Hopkins University, to serve on a special task force to study the benefits of nanobiotechnology.

According to the governor’s office, the mission of the task force is “to study the benefits of nanobiotechnology including job creation, the development of lifesaving treatments, reductions in health care costs, the development of state-of-the-art electronics, medical equipment, chemical processes and other commercial products.”

Nanotechnology involves the application of materials and devices at the scale of just a few atoms in diameter. Nanobiotechnology attempts to apply these tiny technologies to medicine and basic science.

Searson is the Joseph R. and Lynn C. Reynolds Professor of Engineering in the university’s Whiting School of Engineering. He is a professor in the Department of Materials Science and Engineering, and he directs the Johns Hopkins Institute for NanoBioTechnology. He received his Ph.D. from the University of Manchester in England and was a postdoctoral associate at the Massachusetts Institute of Technology. He lives in Baltimore.

Desiderio is director of the Institute of Basic Biomedical Sciences, director of the Immunobiology Program at the Institute for Cell Engineering and a professor of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine. Desiderio earned his M.D. and a Ph.D. from the Johns Hopkins University School of Medicine and was a postdoctoral fellow at the Massachusetts Institute of Technology. Desiderio also lives in Baltimore.

Both Searson and Desiderio are involved with research related to nanobiotechnology. Searson’s interests include nanoscience, biophysics and bioengineering. He led the launch of the Institute for Nanobiotechnology, which was established in 2006 as a cross-divisional center with research interests in the basic sciences, engineering, medicine and public health.

Desiderio’s research focuses on the immune system: how immune cells are able to recognize a diverse number of pathogens and respond to environmental cues. He studies the molecular and genetic mechanisms underlying the development of the immune system. In 2007, Desiderio was appointed by O’Malley to the Maryland Life Sciences Advisory Board.

The nanobiotechnology task force will be chaired by state Sen. Jennie M. Forehand and Del. Susan C. Lee. In addition to Searson and Desiderio, task force members include Nariman Farvadin, Peter Swaan, Esther H. Chang, Lisbeth Pettengill, Patrick Y. Lu and Lawrence Tamarkin.

Along with examining the scientific and medical benefits of nanobiotechnology, the task force members expect to look at the economic impact that the development of such technologies might have on the state of Maryland, including the creation of jobs.

The governor’s office also stated that the group will study the “generation of revenue for the state and improvements to the quality of life for the state’s citizens and the state’s role in supporting Maryland’s leadership in nanobiotechnology, including: promoting public-private partnerships; assisting companies in technology transfers, including from research to commercial product; promoting research; protecting intellectual property; offering appropriate financial incentives; including tax credits; and capturing and leveraging federal funds for both public and private ventures; and make recommendations regarding actions that the state should take to promote the growth of the nanobiotechnology industries in the state.”

MedImmune scientist focuses final INBT seminar on ‘soft skills’


Ambarish Shah of MedImmune

Ambarish Shah, Senior Manager and Principal Scientist at MedImmune Inc., presented the final Professional Development Seminar talk hosted by the Johns Hopkins Institute for NanoBioTechnology (INBT) on July 28. Shah’s presentation included an overview of the Biopharmaceutical industry and offered an insider’s perspective on how MedImmune manages the process of protein drug development.

Shah stated that “success in your careers will not only depend on how well you master the scientific principles in theory but more so how you apply them innovatively,” impressing upon students the value of applying science to solving practical problems. In addition, he stressed the acquisition of “soft skills” along with science, such as people skills and networking. Shah stressed the importance of protecting one’s intellectual property, as well as the safety and efficacy of a product. Despite the risks and costs, he urged students to always remember the altruistic purpose behind their work, cautioning: “don’t get attached to projects, get attached to science.”

Due to the fact that new research in the field is presented at technical conferences or published in peer reviewed journals, scientists tend to speak in technical terms that are too complex for the general public to understand. Shah stated that the field is missing “the clarity in linking what we do scientifically in our labs to the tangible benefits the general public end user will see, and a good forum to share it in.”

Shah offered students insight in understanding career development, stating that career success comes from a combination of many good personal attributes such as clarity of communication, willingness to a make a persistent effort, teamwork, and of course an analytical problem solving mind (all of these which can be learned through deliberate practice). Most importantly he advised students that “Grades and publications matter, but just to get the first job. After the first job, the only thing that matters is demonstrated results.”

Shah received his PhD in Pharmaceutical Sciences from Mercer University in 1998, a Master of Science from Duquesne University, and a Bachelor of Pharmacy from Bombay University in India. He has been in the field for over twelve years and is currently the Principal Scientist/Group leader for MedImmune’s Dept. of Formulation Sciences in Gaithersburg, Md.

Story by Sarah Gubara, Senior, Psychology, Krieger School of Arts and Sciences

Postdocs share how they manage work-life balance at July 14 INBT seminar

The life of a researcher can be hectic and complex. Add to that the responsibilities of family, friends, and the career and needs of a spouse or partner, even children, and it could spell trouble. Eric Balzer, Zev Binder, Daniele Gilkes and Sam Walcott, all postdoctoral fellows associated with Johns Hopkins Institute for NanoBioTechnology, will conduct a panel discussion highlighting the challenges of balancing work and family on July 14 at 11 a.m. in 234 Ames. The discussion is part of INBT’s professional development seminars. RSVP to Ashanti Edwards, Ashanti@jhu.edu. This talk is free and open to all faculty, staff and students.

For more information visit http://inbt.jhu.edu

Beyond academia and industry

Penelope Lewis, acquisitions editor at the American Chemical Society, spoke at the summer’s second Professional Development Seminar hosted by The Johns Hopkins Institute for NanoBioTechnology (INBT) on June 30 at 11 a.m. in Maryland Hall 110.

Penelope Lewis, acquisitions editor at the American Chemical Society (Photo: Mary Spiro)

Lewis discussed her experience as a scientist making the transition to non-profit, scholarly publishing.

As a PhD candidate, she felt she had only two options: academia or industry. She cautioned against having “too much of a single-minded focus,” as students can get “wrapped up in studying or getting stuck in the lab.” Lewis stressed the importance of having a broad outlook and being involved in a variety of activities to know where one’s true skills and interests lie.

Penelope Lewis advocated for an interactive and investigative approach to understanding career development: “My main piece of advice is to keep your eyes and ears open when considering different careers.” Academic publishing allowed Lewis to combine her interest in writing (she minored in English) with her love of science.

“Being able to communicate your research findings and their significance is such a critical skill. It is necessary not only for securing grants and publishing papers, but also as part of a responsibility that scientists and engineers have to act as good ambassadors for science, and to transfer their excitement and understanding to the public. This is especially important in newer fields like nanotechnology,” she said.

Penelope Lewis has a BS in Chemistry (English Minor) from Indiana University, a Chemistry PhD from Pennsylvania State University, and was a Postdoctoral Research Scientist at Columbia University.

For more information about INBT’s professional development seminars, click here.

Story by Sarah Gubara, Senior, Psychology, Krieger School of Arts and Sciences

Melissaratos opens INBT summer seminar series, June 16

Aris Melissaratos, senior advisor to the president for enterprise development at Johns Hopkins Technology Transfer, will speak at the summer’s first Professional Development Seminar hosted by the Johns Hopkins Institute for NanoBioTechnology (INBT) on June 16 at 11 a.m. in Maryland Hall 110.

A Hopkins’ electrical engineering graduate (‘66), Melissaratos will discuss the importance of technology on academic development and how it affects the standard of living, opportunities of the future, and solves global discrepancies. Melissaratos claims that he has “lots of warnings and advice” to offer, in addition to the benefit of “50 years of industry” experience.

Wednesday’s talk will include excerpts and topics from his new book, Innovation: The Key to Prosperity—Technology and America’s Role in the 21st Century Global Economy, cowritten with N.J Slabbert, which focuses on the translation side of the industry and how to transfer technology. The book “reveals America’s greatest wealth: its scientific and inventive ingenuity” and discusses how to harness and utilize that wealth for its full potential.

Melissaratos is a whiz at developing and financing a product and creating a business around a product. A true product of a research institute, Melissaratos” book “reminds us of the power and adventure of human intelligence,” wrote Gilbert F. Decker, former Science Advisor to the US Secretary of Defense in a review of the book. Topics to look forward to include: redeveloping the American economy to regain supremacy, upping our competitive edge in the global economy, and making up for our country’s lost manufacturing base with research.

Melissaratos has previously served as the vice president of science and technology and chief technology officer at Westinghouse Electronics corporate headquarters in Pittsburgh. He left to join state government in 2003 as Secretary of the Maryland Department of Business and Economic Development. His list of impressive credentials include holding the vice presidency title at Thermo Electron Corp., founding Armel Private Equity Investments, founding the Greater Baltimore Technology Council (co-chair), and serving as vice president of the Maryland Chamber of Commerce.

Four seminars will be held this summer. To attend any of INBT’s Professional Development Seminars, RSVP to Ashanti Edwards at Ashanti@jhu.edu.

For more information: INBT Professional Development Seminar Series, The Aris Institute

Story by Sarah Gubara, Senior, Psychology, Krieger School of Arts and Sciences

INBT welcomes 16 summer nanobio research interns

For 10 weeks this summer, 16 students from universities across the country will join the highly competitive Johns Hopkins Institute for Nanobiotechnology (INBT) Research Experience for Undergraduates (REU). The internship is funded by the National Science Foundation (NSF) and is supported and administered by INBT.

This is the third year of INBT’s REU program, and this group represents the institute’s largest group. Students are being mentored by faculty, graduate students and postdoctoral fellows in INBT affiliated laboratories across Hopkins. At the end of the 10-week research program, they will present their findings at a university-wide collaborative research poster session held with other summer interns from across several divisions.

In November 2009, NSF reported that over the last decade 10 times more white students will have earned doctoral degrees in science and engineering disciplines than minority students. Acknowledging this fact yet resolving not to accept it as status quo, INBT has employed aggressive measures to increase the number of individuals from underrepresented groups who apply to its educational programs.

“The nanobiotechnology REU has been one of the most successful and popular programs for INBT,” says Ashanti Edwards, senior education program coordinator for the institute. “The program has consistently attracted the best and the brightest students interested in research from top universities across the nation. The REU program was launched as a conduit to attract highly talented and motivated research students to pursue academic careers in research, particularly women and minority scholars. The program is highly competitive. For summer 2010, the number of applicants for the 10 slots in the program rose to nearly 500, twice what it had been the year before.”

Johns Hopkins Institute for NanoBioTechnology Summer REU Students. (Photos by Mary Spiro)

INBT’s summer 2010 REU students include pictured from top to bottom, from left to right:

Top row

Joshua Austin, computer science and math major from UMBC, is working with Jeff Gray, associate professor of chemical and biomolecular engineering, Whiting School of Engineering.

Mary Bedard, biochemistry and Spanish major from Elon University, is working with J.D. Tovar, assistant professor of chemistry, Krieger School of Arts and Sciences.

Kameron Black, neuroscience major from the University of California, Riverside, is working in the lab of Ted Dawson, professor of neuroscience, School of Medicine

Obafemi Ifelowo, who majors in molecular biology, biochemistry and bioinformatics at Towson University, is working with Jordan Green, assistant professor of biomedical engineering, School of Medicine.

Second row

Alfred Irungu, mechanical engineering major at UMBC, is working with German Drazer, assistant professor of chemical and biomolecular engineering, Whiting School of Engineering.

Ceslee Montgomery, human biology major from Stanford University, is working in the lab of Doug Robinson, associate professor of cell biology, School of Medicine.

Makeda Moore, biology major from Alabama A & M University, is working with Sharon Gerecht, assistant professor of chemical and biomolecular Engineering, Whiting School of Engineering.

Christopher Ojeda, biomedical engineering major from New Jersey Institute of Technology, is working in the lab of Michael Yu, assistant professor of Materials Science and Engineering, Whiting School of Engineering.

Third row

Katrin Passlack, mechanical engineering and kinesiology major at the University of Oklahoma, is working with Jeff Wang, associate professor of mechanical engineering, Whiting School of Engineering.

Roberto Rivera, chemical engineering major from the University of Puerto Rico, Mayaguez, is working in the lab of Nina Markovic, associate professor of physics, Krieger School of Arts and Sciences.

D. Kyle Robinson, bioengineering major from Oregon State University, is working in the lab of Denis Wirtz, professor of chemical and biomolecular engineering, Whiting School of Engineering. In addition, Kyle is the first REU intern for Johns Hopkins new Engineering in Oncology Center, of which Wirtz is director.

Russell Salamo, biology major from the University of Arkansas, is working with Kalina Hristova, associate professor of materials science and engineering, Whiting School of Engineering.

Bottom row

Quinton Smith, major in chemical engineering with a bioengineering concentration from the University of New Mexico, is working with Sharon Gerecht, assistant professor of chemical and biomolecular engineering, Whiting School of Engineering.

David To, chemistry major from Wittenberg University, is working with assistant professor Hai-Quan Mao in the department of materials science and engineering, Whiting School of Engineering.

Alan Winter, biology systems engineering major from Kansas State University, is working with Professor Peter Searson in the department of materials science and engineering, Whiting School of Engineering. Searson is the director of INBT.

Mary Zuniga, biology major a Northern Arizona University, is working in the lab of David Gracias, associate professor of chemical and biomolecular engineering, Whiting School of Engineering.

Related Links:

Johns Hopkins NanoBio Research Experience for Undergraduates