HHMI Student Profile: Patrick Stahl

Picture of Patrick StahlPatrick Stahl. Graduate student in the NBMed program. Credit: Mary Spiro / JHU

The interface between materials science and nanotechnology for biomedical applications is not only exciting but tremendously useful because it can change people’s lives,“ says Patrick Stahl, a first-year Materials Science and Engineering (MSE) pre-doctoral student. Stahl studies collagen mimetic peptides (CMP)—short biopolymers made of the same amino acids found in natural collagen—with Michael Yu, associate professor of materials science and engineering and Institute for NanoBioTechnology (INBT) member.

Stahl is a Nanotechnology for Biology and Medicine fellow funded by the Howard Hughes Medical Institute (HHMI) through INBT. The HHMI program trains students in nanotechnology, biology, and medicine to create diagnostics and therapeutics to detect, treat, and prevent human disease.

CMP forms a triple helix, Stahl says, that can be used to form nanoscale scaffolds to produce hydrogels upon which cells are coaxed to grow. “CMP creates both chemical and physical crosslinks. You can modify the mechanical properties and add biomolecules that will help cells proliferate,“ Stahl says. Ultimately, hydrogels could be implanted into living tissue to aid in wound healing or even organ regeneration.

Stahl enjoys the close knit atmosphere of MSE. “Many faculty members here are young, which brings a certain amount of energy to the program as well as a closer connection between students and professors. Furthermore, the collaboration between materials science and other departments enables unique, interdisciplinary research.“

A 2007 graduate of the University of Maryland, College Park (UMCP) with a BS in materials science, Stahl explored medical applications of engineering while conducting research on ceramic dental replacements. Through UMCP’s Gemstone Program—a four-year multidisciplinary research experience at its engineering school—Stahl helped analyze the chemical composition of over-the-counter ginseng products and created a patient education program to increase awareness about potentially dangerous interactions between herbal supplements and prescription pharmaceuticals.

When not working in the lab, Stahl enjoys playing sports such as tennis, golf and soccer. Although he has spent most of his life in Bethesda, Md., he says that many people are surprised to discover his international roots. “I was born in Geneva, Switzerland and spoke French and German long before I learned English,“ he says.

A life of science, however, was practically unavoidable for Stahl, whose parents both worked for the National Institutes of Health. “I guess you could say I grew up in a scientific household,“ he adds.

Johns Hopkins NanoBioTechnology highlighted in BioSynergy magazine

Johns Hopkins NanoBioTechnology highlighted in BioSynergy magazine

The June 2008 issue of BioSynergy, a University of Toronto based biotechnology magazine, contains two articles highlighting the comments of academic and research leaders at Johns Hopkins University. The story, “An Academic Venture Capitalist“ features an interview with university president William R. Brody.

“Probing the Academic-Industry Partnership at Johns Hopkins: Forging Innovative Biotechnology Tools for Healthcare“ is a question and answer with Johns Hopkins School of Medicine faculty members Martin Pomper, professor of Radiology and Oncology and Institute for NanoBioTechnolgy executive committee member, and Elizabeth M. Jaffee, professor of Oncology and Pharmacology and Molecular Sciences, and Peter C. Searson, the John R. and Lynn C. Reynolds Professor or Materials Science and Engineering and INBT director. The articles begin on pages 128 and 134 respectively of the magazine, and the entire issue of BioSynergy may be downloaded as a pdf at http://www.biosynergyonline.com/contents.php?page=4

INBT on Facebook

The Institute for NanoBioTechnology at Johns Hopkins University recently launched a profile on the social networking Web site Facebook.com. The page is called “Friends of the Institute for NanoBioTechnology at Johns Hopkins University“ and already has 33 members since it was created on July 11, 2008. Anyone may view the INBT Facebook page by going to http://www.facebook.com/pages/Baltimore-MD/Institute-for-NanoBioTechnology-at-Johns-Hopkins-University/19069767276

To participate in discussions, post topics, and upload images or video, one must create a Facebook profile.

INBT Launches Summer Seminars with CytImmune CEO

Picture of Lawrence TamarkinLawrence Tamarkin. Credit: Mary Spiro / JHU

“One of the biggest challenges in technology transfer is to prove to the FDA that what was made in the lab can be made on a large scale to the same quality standards,“ said Lawrence Tamarkin, president and CEO of CytImmune Sciences. Tamarkin presented the first talk of the summer professional development series hosted by the Institute for NanoBioTechnology at Johns Hopkins University. CytImmune Sciences will soon begin Phase 2 clinical trials on a colloidal gold based product that provides targeted and concentrated delivery of a tumor destroying substance.

INBT’s summer professional development series offers students an opportunity to learn from industry representatives on a number of topics related to research and relevant to success in the sciences. Topic range for protecting ones intellectual property to seeking venture capital support,

“These talks allow the students to expand their ideas beyond the focus on their research,“ says Denis Wirtz professor of chemical and biomolecular engineering in the Whiting School of Engineering and associate director of INBT. “It also gives them a better perspective on the ways their research can help society.“

Wirtz added that Tamarkin’s talk highlighted the importance of persistence in research. “Tamarkin emphasized how one must multitask—you must care about the science and manage the public perception of nanoscience as well.“

Talks begin at 11 a.m. and are held in room 303 of Shafer Hall. To attend any of the seminar series talks listed below, please RSVP to Ashanti Edwards via e-mail at aedwards@jhu.edu or by phone at 410-516-6572.

Upcoming professional development talks are:

* July 9
* July 23
* August 6

Health and the Environment Form Focus of Latest NanoBio Seed Grants


Cross-sectional autoradiograms of rodent brains showing (A) control physiological state; and (B) and (C) showing
distribution of brain injury from an injected neurotoxicant. Red areas indicate the highest concentrations of a
biomarker that identifies brain areas that are damaged by the neurotoxicant. Credit: Guilarte Lab

Little is known about how engineered nanomaterials and nanoparticles impact human health and the environment. Particles at the scale of one-billionth of a meter—so small they can slip across the blood-brain barrier—pose many questions about the safety of nanotechnology used in products consumed and used by humans. The Institute for NanoBioTechnology at Johns Hopkins University recently awarded $100,000 to fund research projects that seek to answer these questions. Four $25,000 seed grants were given to multidisciplinary research teams to fund pilot projects across Johns Hopkins. [Read more...]

INBT to Fund Postdocs in NanoTech for Cancer Medicine

The Institute for NanoBioTechnology at Johns Hopkins University has been awarded a $1.6 million T-32 National Cancer Institute training grant to recruit two outstanding trainees every year with MD and/or PhD degrees and diverse backgrounds in either biochemistry, physics, molecular/cellular/cancer biology, or an engineering/physics discipline. Postdoctoral fellows will conduct research in nanotechnology for cancer medicine. Please check the Website of the Institute for NanoBioTechnology in the coming weeks for more details on this exciting opportunity and information about how to apply.

Hopkins NanoBioTech Director Named First Reynolds Professor

Picture of Peter Searson
Peter Searson. Credit: INBT / JHU

Peter Searson, professor of Materials Science and Engineering in the Whiting School of Engineering at Johns Hopkins University and director of the Institute for Nanobiotechnology, has been named the inaugural Joseph R. and Lynn C. Reynolds Professor.

Searson’s research interests include the synthesis and characterization of nanostructured materials, electrodeposition and patterning, and applications for nanotechnology in biology and medicine. He led the launch of the Institute for Nanobiotechnology, which was established May 15, 2006 as a cross-divisional center with research interests in the basic sciences, engineering, medicine and public health. Searson joined the Department of Materials Science and Engineering in 1990, having received his PhD in 1982 from the University of Manchester Institute of Science and Technology.

Joseph Reynolds earned his bachelor’s degree in electrical engineering from Johns Hopkins in 1969. He is the founder and CEO of RTI Consulting LLP, founded FTI Consulting Inc., is a university trustee, and is the current chair of the National Advisory Council. In making the gift of this professorship, Reynolds’ vision was to give the dean and the school the flexibility to select a recipient from any department in the Whiting School of Engineering.

For more information about the Searson Group go to http://www.jhu.edu/matsci/people/faculty/searson/PCSgrouphome.html

IGERT Student Profile: Lindsey Smith

To optimize the strength of materials and structures used in biomedical applications, one must apply the principles of mechanics. This can become a challenging task in these multiphysics settings, says Lindsey Smith, a second year doctoral student in civil engineering at Johns Hopkins University. Smith is a member of the NanoBio IGERT with the Institute for NanoBioTechnology. Funded by the National Science Foundation, IGERT stands for Integrative Graduate Education and Research Traineeship.

Smith’s interest in structures and engineering blossomed after taking a high school introductory course on the topic. “I was always strong in math and science,“ she says. “I also was fascinated with architecture and large buildings.“ Smith graduated in 2003 from Columbia University with a major in Engineering Mechanics, which she describes as the study of the application of mechanics to civil engineering. [Read more...]

Water: More Than Just a Drink

Faculty Profile: Dilip Asthagiri


To understand electrical activity of nerve cells, the Asthagiri Lab develops simulations that show selectivity of
channel proteins (in green) for potassium ions (in purple). Credit: Asthagiri Group / JHU

In his book “Life’s Matrix: A biography of water,“ author and Nature consulting editor Philip Ball declares that water is the “weirdest liquid.“ Dilip Asthagiri, assistant professor of chemical and biomolecular engineering, would agree. “There are very many puzzling features in all of aqueous chemistry and biology,“ says Asthagiri, an affiliated faculty member of the Institute for NanoBioTechnology. With a sub nanoscale diameter of about 3 Angstroms (0.3 nanometer), Asthagiri says, the water molecule is “more ‘nano’ than nano“ and an understanding of water is integral to this emerging science. [Read more...]

Gerecht’s Stem Cell Research Nets Outstanding Young Engineer Award

Picture of Sharon Gerecht
Sharon Gerecht. Credit: INBT / JHU

Assistant Professor Sharon Gerecht, an affiliated faculty member of the Institute for NanoBioTechnology in the Department of Chemical and Biomolecular Engineering at Johns Hopkins University, recently earned the Maryland Academy of Science’s 2008 Outstanding Young Engineering (OYE) award. The OYE award recognizes the extraordinary scientific contributions of Maryland residents under the age of 35.

Gerecht studies how changes in micro- and nano-scale environment can affect the growth and function of stem cells with focus on vascular development and regeneration. Gerecht is looking at ways to direct stem cell differentiation by engineering different chemical, mechanical and physical environments upon which the cells grow. This may have implications on how stem cells could be used in medical therapy.

“I believe that we are now in a unique position in which we know more about stem cells, their isolation, characterization, and have a basic understanding of their biology,“ says Gerecht. “This enables us to integrate advanced microengineering tools to better control their behavior both in the lab and in the body after transplantation“

As part of her award, Gerecht received a $2,500 cash prize and the Allan C. Davis Medal, named for the former Science Center board chairman whose gift helped fund construction of the Davis Planetarium. The Maryland Science Center, located at Baltimore’s Inner Harbor, is visited by more than 500,000 people each year.

Gerecht is the third INBT affiliated faculty member to be honored with an award from the Maryland Science Center. In 2007 David Gracias, also an assistant professor in the in the Department of Chemical and Biomolecular Engineering, received the OYE award. And in 2006, Anirban Maitra, associate professor of oncology and pathology at the Sol Goldman Pancreatic Cancer Research Center, was awarded the center’s Outstanding Young Scientist Award.

More about Gerecht’s research: http://www.jhu.edu/chembe/gerecht/