Betenbaugh research seeks better control of antibody production

Antibodies are blood proteins created by the immune system in response to a certain antigen. Antibodies have become the chief component in myriad medicine applications from diagnostic tests to several widely used pharmaceuticals for the treatment of asthma, arthritis, cancer and more.

How handy would it be to be able control the function of the antibodies made in a lab, simply by tweaking the nutrient media that you used to grown them in? And how useful would it be, if you could increase the quantity of antibodies produced, also be modifying the media in which they were created?


Bound for destruction: Y-shapted antibody binds t-cell and macrophage to tumor cell.

Pharmaceutical manufacturers seek more efficient ways to grow genetically engineered human antibodies on a large scale. Through a partnership with MedImmune, researchers in the laboratory of Michael Betenbaugh are taking an engineering approach to the solution. Betenbaugh, professor of Chemical and Biomolecular Engineering and an affiliate of Johns Hopkins INBT, seeks to discover ways to improve the growth media for the antibody-producing microbes. Their lab is not only looking at more efficient ways to grow large quantities of antibodies via microbes but also to find out if the properties of the antibodies can be influenced by the properties of the media in which the microbes are grown.

To read more about this research and the partnership with MedImmune, visit this link.

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